Sign in or Register   Sign in or Register
  |  

Mouse Anti-IL21R Recombinant Antibody (CBYY-I1101) (CBMAB-I2269-YY)

This product is Mouse antibody that recognizes IL21R. The antibody CBYY-I1101 can be used for immunoassay techniques such as: ELISA
See all IL21R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I1101
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 21 Receptor
Introduction
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Entrez Gene ID
UniProt ID
Alternative Names
Interleukin 21 Receptor
Function
This is a receptor for interleukin-21.
Biological Process
Natural killer cell activation1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 56 (IMD56):
An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens.
Topology
Extracellular: 20-232
Helical: 233-253
Cytoplasmic: 254-538
PTM
C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

Luo, W., Conter, L., Elsner, R. A., Smita, S., Weisel, F., Callahan, D., ... & Shlomchik, M. (2023). IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells. Science Immunology, 8(80), eadd1823.

Yang, S., Zeng, J., Hao, W., Sun, R., Tuo, Y., Tan, L., ... & Bai, H. (2023). IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection. International Journal of Molecular Sciences, 24(16), 12557.

Szabó, K., Jámbor, I., Pázmándi, K., Nagy, N., Papp, G., & Tarr, T. (2022). Altered circulating follicular T helper cell subsets and follicular T regulatory cells are indicators of a derailed B cell response in lupus, which could be modified by targeting IL-21R. International Journal of Molecular Sciences, 23(20), 12209.

Ahmad, S. F., Ansari, M. A., Nadeem, A., Bakheet, S. A., Alsanea, S., Al-Hosaini, K. A., ... & Attia, S. M. (2020). Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism. Neurotoxicology, 77, 1-11.

Xue, D., Yang, P., Wei, Q., Li, X., Lin, L., & Lin, T. (2019). IL‑21/IL‑21R inhibit tumor growth and invasion in non‑small cell lung cancer cells via suppressing Wnt/β‑catenin signaling and PD‑L1 expression. International Journal of Molecular Medicine, 44(5), 1697-1706.

Yan, L., Zhang, J., Guo, D., Ma, J., Shui, S. F., & Han, X. W. (2019). IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer. International Journal of Oncology, 54(1), 7-16.

Dinesh, P., & Rasool, M. (2019). Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. Apoptosis, 24(7-8), 644-661.

Dam, E. M., Maier, A. C., Hocking, A. M., Carlin, J., Ng, B., & Buckner, J. H. (2018). Increased binding of specificity protein 1 to the IL21R promoter in B cells results in enhanced b cell responses in rheumatoid arthritis. Frontiers in Immunology, 9, 1978.

Dinesh, P., & Rasool, M. (2018). Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated osteoclastogenesis. Cytokine, 106, 54-66.

Huang, Y., Zhang, J., Wang, G., Chen, X., Zhang, R., Liu, H., & Zhu, J. (2018). Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway. International journal of immunopathology and pharmacology, 32, 2058738418781634.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-IL21R Recombinant Antibody (CBYY-I1101)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare