IL21R

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Full Name
Interleukin 21 Receptor
Alternative Names
Interleukin 21 Receptor
Function
This is a receptor for interleukin-21.
Biological Process
Natural killer cell activation1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 56 (IMD56):
An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens.
Topology
Extracellular: 20-232
Helical: 233-253
Cytoplasmic: 254-538
PTM
C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
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Anti-IL21R antibodies

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Rat Anti-IL21R Recombinant Antibody (AG105) (V2LY-0524-LY148)

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Target: IL21R
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG105
Application*: B, F, In Vivo, IP
In Vivo Assay Functional Assay
Datasheet SDS

Human Anti-IL21R Recombinant Antibody (CBXC-0759) (CBMAB-C1873-CQ)

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Target: IL21R
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0759
Application*: F
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBT2820) (V2LY-0625-LY1675)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2820
Application*: IC, F
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBT3145) (V2LY-0625-LY1575)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3145
Application*: F
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBT3510) (V2LY-0625-LY1120)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3510
Application*: F
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBT3691) (V2LY-0625-LY1119)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3691
Application*: WB
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (A535) (CBMAB-AP10887LY)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A535
Application*: ELISA, IHC, WB
Datasheet SDS

Rat Anti-IL21R Recombinant Antibody (CBWJC-3814) (CBMAB-C5083WJ)

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Target: IL21R
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-3814
Application*: F
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBFYC-0334) (CBMAB-C0372-FY)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0334
Application*: F
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBYY-I1459) (CBMAB-I2629-YY)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1459
Application*: WB
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBYY-I1101) (CBMAB-I2269-YY)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1101
Application*: E
Datasheet SDS

Rat Anti-IL21R Recombinant Antibody (7F27) (CBMAB-I1670-YY)

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Target: IL21R
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 7F27
Application*: WB
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBYY-I0183) (CBMAB-I0500-YY)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: CBYY-I0183
Application*: F
Datasheet SDS

Rat Anti-IL21R Recombinant Antibody (CBYY-I0182) (CBMAB-I0498-YY)

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Target: IL21R
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0182
Application*: WB
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (152512) (CBMAB-I0497-YY)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 152512
Application*: F, MC
Datasheet SDS

Mouse Anti-IL21R Recombinant Antibody (CBYY-I0181) (CBMAB-I0496-YY)

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Target: IL21R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0181
Application*: WB
Datasheet SDS

Rat Anti-IL21R Recombinant Antibody (4A9) (CBMAB-1038-LY)

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Target: IL21R
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 4A9
Application*: B
Functional Assay
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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