Mouse Recombinant IL21R protein, ECD, His Tag (V2LY-0526-LY8516)

Name: Mouse Recombinant IL21R protein, ECD, His Tag
SKU: V2LY-0526-LY8516
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant IL21R protein, ECD, His Tag consist of Amino Acid: 1-236 and predicts a molecular mass of 26.3 kDa.

Molecule Mass

26.3 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 1-236

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Sodium phosphate, NaCl, Imidazole, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 21 Receptor

Alternative Names

Interleukin 21 Receptor

Function

This is a receptor for interleukin-21.

Biological Process

Natural killer cell activation1 PublicationNAS:UniProtKB

Cellular Location

Membrane

Involvement in disease

Immunodeficiency 56 (IMD56):
An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens.

Topology

Extracellular: 20-232
Helical: 233-253
Cytoplasmic: 254-538

PTM

C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

Luo, W., Conter, L., Elsner, R. A., Smita, S., Weisel, F., Callahan, D., ... & Shlomchik, M. (2023). IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells. Science Immunology, 8(80), eadd1823.

Yang, S., Zeng, J., Hao, W., Sun, R., Tuo, Y., Tan, L., ... & Bai, H. (2023). IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection. International Journal of Molecular Sciences, 24(16), 12557.

Szabó, K., Jámbor, I., Pázmándi, K., Nagy, N., Papp, G., & Tarr, T. (2022). Altered circulating follicular T helper cell subsets and follicular T regulatory cells are indicators of a derailed B cell response in lupus, which could be modified by targeting IL-21R. International Journal of Molecular Sciences, 23(20), 12209.

Ahmad, S. F., Ansari, M. A., Nadeem, A., Bakheet, S. A., Alsanea, S., Al-Hosaini, K. A., ... & Attia, S. M. (2020). Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism. Neurotoxicology, 77, 1-11.

Xue, D., Yang, P., Wei, Q., Li, X., Lin, L., & Lin, T. (2019). IL‑21/IL‑21R inhibit tumor growth and invasion in non‑small cell lung cancer cells via suppressing Wnt/β‑catenin signaling and PD‑L1 expression. International Journal of Molecular Medicine, 44(5), 1697-1706.

Yan, L., Zhang, J., Guo, D., Ma, J., Shui, S. F., & Han, X. W. (2019). IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer. International Journal of Oncology, 54(1), 7-16.

Dinesh, P., & Rasool, M. (2019). Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. Apoptosis, 24(7-8), 644-661.

Dam, E. M., Maier, A. C., Hocking, A. M., Carlin, J., Ng, B., & Buckner, J. H. (2018). Increased binding of specificity protein 1 to the IL21R promoter in B cells results in enhanced b cell responses in rheumatoid arthritis. Frontiers in Immunology, 9, 1978.

Dinesh, P., & Rasool, M. (2018). Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated osteoclastogenesis. Cytokine, 106, 54-66.

Huang, Y., Zhang, J., Wang, G., Chen, X., Zhang, R., Liu, H., & Zhu, J. (2018). Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway. International journal of immunopathology and pharmacology, 32, 2058738418781634.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL21R protein, His Tag (CAT#: V2LY-0526-LY1567)

Cynomolgus, Rhesus Recombinant IL21R protein, hFc Tag (CAT#: V2LY-0526-LY1721)

Human Recombinant IL21R protein, hFc Tag (CAT#: V2LY-0526-LY4837)

Human Recombinant IL21R protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4838)

Human Recombinant IL21R protein, His Tag (CAT#: V2LY-0526-LY4839)

Mouse Recombinant IL21R protein, hFc Tag (CAT#: V2LY-0526-LY8517)

Rat Recombinant IL21R protein, His Tag (CAT#: V2LY-0526-LY9460)

Rat Recombinant IL21R protein, Fc Tag (CAT#: V2LY-0526-LY9461)

Related Products

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Cynomolgus Recombinant IL21R protein, His Tag (CAT#: V2LY-0526-LY1567)

Mouse Anti-IL21R Recombinant Antibody (CBYY-I0181) (CAT#: CBMAB-I0496-YY)

Rat Recombinant IL21R protein, His Tag (CAT#: V2LY-0526-LY9460)

Rat Anti-IL21R Recombinant Antibody (AG105) (CAT#: V2LY-0524-LY148)

Rat Recombinant IL21R protein, Fc Tag (CAT#: V2LY-0526-LY9461)

Cynomolgus, Rhesus Recombinant IL21R protein, hFc Tag (CAT#: V2LY-0526-LY1721)

Mouse Anti-IL21R Recombinant Antibody (CBT2820) (CAT#: V2LY-0625-LY1675)

Rat Anti-IL21R Recombinant Antibody (4A9) (CAT#: CBMAB-1038-LY)

Human Recombinant IL21R protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4838)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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