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Rat Anti-IL21R Recombinant Antibody (4A9) (CBMAB-1038-LY)

This product is rat antibody recognizes mouse IL-21R. The antibody 4A9 immunoassay techniques such as: Blocking.
See all IL21R antibodies
Published Data
Fig.1 Il2-emGFP-Il21-mCherry dual reporter transgenic mice were infected with low dose LCMV-WE or high dose LCMV-DOC.
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Fig.2 FACS plots show CD25 and Foxp3 expression of CD4+ T cells.
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Fig.3 IL-21R expression on BM B cell progenitors.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
4A9
Antibody Isotype
IgG2a
Application
Blocking

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 21 Receptor
Introduction
This is a receptor for interleukin-21.
Entrez Gene ID
60504
UniProt ID
Q9JHX3
Alternative Names
NILR
Function
This is a receptor for interleukin-21.
Biological Process
Natural killer cell activation1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 56 (IMD56):
An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens.
Topology
Extracellular: 20-232
Helical: 233-253
Cytoplasmic: 254-538
PTM
C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

Luo, W., Conter, L., Elsner, R. A., Smita, S., Weisel, F., Callahan, D., ... & Shlomchik, M. (2023). IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells. Science Immunology, 8(80), eadd1823.

Yang, S., Zeng, J., Hao, W., Sun, R., Tuo, Y., Tan, L., ... & Bai, H. (2023). IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection. International Journal of Molecular Sciences, 24(16), 12557.

Szabó, K., Jámbor, I., Pázmándi, K., Nagy, N., Papp, G., & Tarr, T. (2022). Altered circulating follicular T helper cell subsets and follicular T regulatory cells are indicators of a derailed B cell response in lupus, which could be modified by targeting IL-21R. International Journal of Molecular Sciences, 23(20), 12209.

Ahmad, S. F., Ansari, M. A., Nadeem, A., Bakheet, S. A., Alsanea, S., Al-Hosaini, K. A., ... & Attia, S. M. (2020). Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism. Neurotoxicology, 77, 1-11.

Xue, D., Yang, P., Wei, Q., Li, X., Lin, L., & Lin, T. (2019). IL‑21/IL‑21R inhibit tumor growth and invasion in non‑small cell lung cancer cells via suppressing Wnt/β‑catenin signaling and PD‑L1 expression. International Journal of Molecular Medicine, 44(5), 1697-1706.

Yan, L., Zhang, J., Guo, D., Ma, J., Shui, S. F., & Han, X. W. (2019). IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer. International Journal of Oncology, 54(1), 7-16.

Dinesh, P., & Rasool, M. (2019). Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. Apoptosis, 24(7-8), 644-661.

Dam, E. M., Maier, A. C., Hocking, A. M., Carlin, J., Ng, B., & Buckner, J. H. (2018). Increased binding of specificity protein 1 to the IL21R promoter in B cells results in enhanced b cell responses in rheumatoid arthritis. Frontiers in Immunology, 9, 1978.

Dinesh, P., & Rasool, M. (2018). Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated osteoclastogenesis. Cytokine, 106, 54-66.

Huang, Y., Zhang, J., Wang, G., Chen, X., Zhang, R., Liu, H., & Zhu, J. (2018). Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway. International journal of immunopathology and pharmacology, 32, 2058738418781634.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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