Mouse Anti-IL21R Recombinant Antibody (152512) (CBMAB-I0497-YY)

Name: Mouse Anti-IL21R Recombinant Antibody (152512)
SKU: CBMAB-I0497-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

152512

Application

FC, CyTOF

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interleukin 21 Receptor

Introduction

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Entrez Gene ID

50615

UniProt ID

Q9HBE5

Alternative Names

Interleukin 21 Receptor

Function

This is a receptor for interleukin-21.

Biological Process

Natural killer cell activation1 PublicationNAS:UniProtKB

Cellular Location

Membrane

Involvement in disease

Immunodeficiency 56 (IMD56):
An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens.

Topology

Extracellular: 20-232
Helical: 233-253
Cytoplasmic: 254-538

PTM

C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

Luo, W., Conter, L., Elsner, R. A., Smita, S., Weisel, F., Callahan, D., ... & Shlomchik, M. (2023). IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells. Science Immunology, 8(80), eadd1823.

Yang, S., Zeng, J., Hao, W., Sun, R., Tuo, Y., Tan, L., ... & Bai, H. (2023). IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection. International Journal of Molecular Sciences, 24(16), 12557.

Szabó, K., Jámbor, I., Pázmándi, K., Nagy, N., Papp, G., & Tarr, T. (2022). Altered circulating follicular T helper cell subsets and follicular T regulatory cells are indicators of a derailed B cell response in lupus, which could be modified by targeting IL-21R. International Journal of Molecular Sciences, 23(20), 12209.

Ahmad, S. F., Ansari, M. A., Nadeem, A., Bakheet, S. A., Alsanea, S., Al-Hosaini, K. A., ... & Attia, S. M. (2020). Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism. Neurotoxicology, 77, 1-11.

Xue, D., Yang, P., Wei, Q., Li, X., Lin, L., & Lin, T. (2019). IL‑21/IL‑21R inhibit tumor growth and invasion in non‑small cell lung cancer cells via suppressing Wnt/β‑catenin signaling and PD‑L1 expression. International Journal of Molecular Medicine, 44(5), 1697-1706.

Yan, L., Zhang, J., Guo, D., Ma, J., Shui, S. F., & Han, X. W. (2019). IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer. International Journal of Oncology, 54(1), 7-16.

Dinesh, P., & Rasool, M. (2019). Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. Apoptosis, 24(7-8), 644-661.

Dam, E. M., Maier, A. C., Hocking, A. M., Carlin, J., Ng, B., & Buckner, J. H. (2018). Increased binding of specificity protein 1 to the IL21R promoter in B cells results in enhanced b cell responses in rheumatoid arthritis. Frontiers in Immunology, 9, 1978.

Dinesh, P., & Rasool, M. (2018). Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated osteoclastogenesis. Cytokine, 106, 54-66.

Huang, Y., Zhang, J., Wang, G., Chen, X., Zhang, R., Liu, H., & Zhu, J. (2018). Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway. International journal of immunopathology and pharmacology, 32, 2058738418781634.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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