Sign in or Register   Sign in or Register
  |  

Mouse Anti-IL26 Recombinant Antibody (510414) (CBMAB-I1378-YY)

This product is Mouse antibody that recognizes IL26 . The antibody 510414 can be used for immunoassay techniques such as: ICFC, CyTOF
See all IL26 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
510414
Antibody Isotype
IgG1
Application
ICFC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
interleukin 26
Introduction
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri.
Entrez Gene ID
55801
UniProt ID
Q9NPH9
Alternative Names
Interleukin 26
Function
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted

Fries, A., Saidoune, F., Kuonen, F., Dupanloup, I., Fournier, N., Guerra de Souza, A. C., ... & Gilliet, M. (2023). Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis. Nature Communications, 14(1), 3878.

Cardenas, E. I., Ekstedt, S., Piersiala, K., Petro, M., Karlsson, A., Kågedal, Å., ... & Lindén, A. (2022). Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19. Frontiers in immunology, 13.

Cardenas, E. I., Che, K. F., Konradsen, J. R., Bao, A., & Lindén, A. (2022). IL-26 in asthma and COPD. Expert Review of Respiratory Medicine, 16(3), 293-301.

Beaumont, É., Larochette, V., Preisser, L., Miot, C., Pignon, P., Blanchard, S., ... & Delneste, Y. (2022). IL-26 inhibits hepatitis C virus replication in hepatocytes. Journal of Hepatology, 76(4), 822-831.

Gowhari Shabgah, A., Abdelbasset, W. K., Sulaiman Rahman, H., Bokov, D. O., Suksatan, W., Thangavelu, L., ... & Gholizadeh Navashenaq, J. (2022). A comprehensive review of IL‐26 to pave a new way for a profound understanding of the pathobiology of cancer, inflammatory diseases and infections. Immunology, 165(1), 44-60.

Itoh, T., Hatano, R., Horimoto, Y., Yamada, T., Song, D., Otsuka, H., ... & Ohnuma, K. (2021). IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Cell Death & Disease, 12(6), 520.

Itoh, T., Hatano, R., Komiya, E., Otsuka, H., Narita, Y., Aune, T. M., ... & Ohnuma, K. (2019). Biological effects of IL-26 on T cell–mediated skin inflammation, including psoriasis. Journal of Investigative Dermatology, 139(4), 878-889.

Larochette, V., Miot, C., Poli, C., Beaumont, E., Roingeard, P., Fickenscher, H., ... & Delneste, Y. (2019). IL-26, a cytokine with roles in extracellular DNA-induced inflammation and microbial defense. Frontiers in immunology, 10, 204.

Dang, A. T., Teles, R. M., Weiss, D. I., Parvatiyar, K., Sarno, E. N., Ochoa, M. T., ... & Modlin, R. L. (2019). IL-26 contributes to host defense against intracellular bacteria. The Journal of clinical investigation, 129(5), 1926-1939.

Hatano, R., Itoh, T., Otsuka, H., Okamoto, S., Komiya, E., Iwata, S., ... & Morimoto, C. (2019, November). Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis. In mabs (Vol. 11, No. 8, pp. 1428-1442). Taylor & Francis.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IL26 Recombinant Antibody (510414)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare