IL26

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq]
Full Name
interleukin 26
Function
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
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Anti-IL26 antibodies

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Mouse Anti-IL26 Recombinant Antibody (510414) (CBMAB-I1378-YY)

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Target: IL26
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 510414
Application*: IS, MC
Mouse Anti-IL26 Recombinant Antibody (510414)
Datasheet SDS

Mouse Anti-IL26 Recombinant Antibody (2A8) (CBMAB-A4399-LY)

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Target: IL26
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A8
Application*: SE, E
Mouse Anti-IL26 Recombinant Antibody (2A8)
Datasheet SDS

Human IL26 ELISA Kit (V2LY-0626-LY257)

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Target: IL26
Sensitivity: 0.23 pg/mL
Detection Range: 0.5-60 pg/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Human IL26 ELISA Kit
Datasheet SDS

Mouse Anti-IL26 Recombinant Antibody (CBYY-I1161) (CBMAB-I2329-YY)

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Target: IL26
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1161
Application*: WB
Mouse Anti-IL26 Recombinant Antibody (CBYY-I1161)
Datasheet SDS

Mouse Anti-IL26 Recombinant Antibody (CBYY-I0193) (CBMAB-I0522-YY)

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Target: IL26
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0193
Application*: WB
Mouse Anti-IL26 Recombinant Antibody (CBYY-I0193)
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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