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Rat Anti-IL27RA Recombinant Antibody (CBYY-I0196) (CBMAB-I0529-YY)

This product is Rat antibody that recognizes IL27RA. The antibody CBYY-I0196 can be used for immunoassay techniques such as: WB
See all IL27RA antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-I0196
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
interleukin 27 receptor, alpha
Introduction
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.
Entrez Gene ID
50931
UniProt ID
O70394
Alternative Names
Interleukin 27 Receptor Subunit Alpha
Function
Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761).
Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-17 productionIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell extravasationIEA:Ensembl
Negative regulation of T-helper 17 type immune responseIEA:Ensembl
Negative regulation of tumor necrosis factor productionIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of activated T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of interferon-gamma productionIEA:Ensembl
Positive regulation of T-helper 1 type immune responseIEA:Ensembl
Regulation of isotype switching to IgG isotypesIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 33-516
Helical: 517-537
Cytoplasmic: 538-636
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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