Mouse Anti-IL27RA Recombinant Antibody (CBYY-I1342) (CBMAB-I2512-YY)

Name: Mouse Anti-IL27RA Recombinant Antibody (CBYY-I1342)
SKU: CBMAB-I2512-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1342

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

interleukin 27 receptor, alpha

Introduction

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.

Entrez Gene ID

9466

UniProt ID

Q6UWB1

Alternative Names

Interleukin 27 Receptor Subunit Alpha

Function

Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761).
Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

Biological Process

Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-17 productionIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell extravasationIEA:Ensembl
Negative regulation of T-helper 17 type immune responseIEA:Ensembl
Negative regulation of tumor necrosis factor productionIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of activated T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of interferon-gamma productionIEA:Ensembl
Positive regulation of T-helper 1 type immune responseIEA:Ensembl
Regulation of isotype switching to IgG isotypesIEA:Ensembl

Cellular Location

Membrane

Topology

Extracellular: 33-516
Helical: 517-537
Cytoplasmic: 538-636

Brownlie, R. J., Kennedy, R., Wilson, E. B., Milanovic, M., Taylor, C. F., Wang, D., ... & Klein, U. (2023). Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma. Blood Advances, 7(15), 3874-3890.

He, H., Xu, P., Zhang, X., Liao, M., Dong, Q., Cong, T., ... & Wang, J. (2020). Aging-induced IL27Ra signaling impairs hematopoietic stem cells. Blood, The Journal of the American Society of Hematology, 136(2), 183-198.

Dibra, D., Xia, X., Gagea, M., Lozano, G., & Li, S. (2018). A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: a process regulated by IL27RA-/-and mutant-p53. PLoS One, 13(3), e0193485.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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