Mouse Anti-IL2RB Recombinant Antibody (7H139) (CBMAB-C0360-CN)

Name: Mouse Anti-IL2RB Recombinant Antibody (7H139)
SKU: CBMAB-C0360-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

7H139

Application

Immunogen

YT-1 acute human leukemia cells

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50 mM Sodium phosphate, pH 7.5, 100 mM potassium chloride, 150 mM NaCl

Preservative

0.5 mg/mL Gentamicin sulfate

Concentration

1 mg/mL

More Infomation

Target

Full Name

Interleukin 2 Receptor Subunit Beta

Introduction

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]

Entrez Gene ID

3560

UniProt ID

P14784

Alternative Names

Interleukin 2 Receptor Subunit Beta

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:MGI
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Involvement in disease

Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63):
An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease.

Topology

Extracellular: 27-240
Helical: 241-265
Cytoplasmic: 266-551

Liao, Y., Ke, B., Long, X., Xu, J., & Wu, Y. (2022). Upregulated expression of IL2RB causes disorder of immune microenvironment in patients with Kawasaki disease. BioMed Research International, 2022.

Li, G., Wang, Y., & Cheng, Y. (2022). IL2RB is a prognostic biomarker associated with immune infiltrates in pan-cancer. Journal of Oncology, 2022.

Cheng, C. C., Lin, H. C., Chiang, Y. W., Chang, J., Sie, Z. L., Yang, B. L., ... & Chang, Y. F. (2021). Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression. Cancer Immunology, Immunotherapy, 70, 1351-1364.

Alderdice, M., Craig, S. G., Humphries, M. P., Gilmore, A., Johnston, N., Bingham, V., ... & McArt, D. G. (2021). Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer. NAR genomics and bioinformatics, 3(2), lqab016.

Lou, W., Yan, J., & Wang, W. (2021). Downregulation of miR-497-5p improves sepsis-induced acute lung injury by targeting IL2RB. BioMed Research International, 2021.

Chen, X., Xingfan, W., Zaozhang, Z., Yuewu, C., & Wang, C. (2021). Role of IL-9, IL-2RA, and IL-2RB genetic polymorphisms in coronary heart disease. Herz, 46(6), 558-566.

Fernandez, I. Z., Baxter, R. M., Garcia-Perez, J. E., Vendrame, E., Ranganath, T., Kong, D. S., ... & Hsieh, E. W. (2019). A novel human IL2RB mutation results in T and NK cell–driven immune dysregulation. Journal of Experimental Medicine, 216(6), 1255-1267.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

Mei, L., Huang, C., Wang, A., & Zhang, X. (2019). Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population. International Immunopharmacology, 77, 105930.

Campbell, T. M., & Bryceson, Y. T. (2019). IL2RB maintains immune harmony. Journal of Experimental Medicine, 216(6), 1231-1233.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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