Sign in or Register

Keywords Search | Target Search

IL2RB

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]

Full Name

Interleukin 2 Receptor Subunit Beta

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:MGI
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Involvement in disease

Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63):
An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease.

Topology

Extracellular: 27-240
Helical: 241-265
Cytoplasmic: 266-551

Anti-IL2RB antibodies

Mouse Anti-IL2RB Recombinant Antibody (CBWJC-3828) (CBMAB-C5099WJ)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3828

Application*: F

Rat Anti-IL2RB Recombinant Antibody (CBWJC-3827) (CBMAB-C5098WJ)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBWJC-3827

Application*: WB

Mouse Anti-IL2RB Recombinant Antibody (CBWJC-2196) (CBMAB-C2982WJ)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJC-2196

Application*: F

Rat Anti-IL2RB Recombinant Antibody (TM-β1) (CBMAB-C3369-CQ)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: TM-β1

Application*: F

Rat Anti-IL2RB Recombinant Antibody (CBXC-1639) (CBMAB-C2923-CQ)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBXC-1639

Application*: F, IP

Rat Anti-IL2RB Recombinant Antibody (CBXC-1399) (CBMAB-C2629-CQ)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXC-1399

Application*: F, IP

Human Anti-IL2RB Recombinant Antibody (CBXC-0725) (CBMAB-C1839-CQ)

SDS

Target: IL2RB

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0725

Application*: F

Rat Anti-IL2RB Recombinant Antibody (CBFYC-2768) (CBMAB-C2844-FY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBFYC-2768

Application*: F, IP

Mouse Anti-IL2RB Recombinant Antibody (CBFYC-2767) (CBMAB-C2843-FY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2767

Application*: F, IH, N

Rat Anti-IL2RB Recombinant Antibody (CBFYC-2766) (CBMAB-C2842-FY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBFYC-2766

Application*: WB

Rat Anti-IL2RB Recombinant Antibody (CBFYC-2765) (CBMAB-C2841-FY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYC-2765

Application*: F

Mouse Anti-IL2RB Recombinant Antibody (CBYY-I1704) (CBMAB-I2874-YY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYY-I1704

Application*: F

Rat Anti-IL2RB Recombinant Antibody (CBYY-I1511) (CBMAB-I2681-YY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-I1511

Application*: F, MC

Rat Anti-IL2RB Recombinant Antibody (CBYY-I1397) (CBMAB-I2567-YY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-I1397

Application*: WB

Rat Anti-IL2RB Recombinant Antibody (5H4) (CBMAB-I1456-YY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 5H4

Application*: F, IH, IP

Rat Anti-IL2RB Recombinant Antibody (TM-Beta1) (CBMAB-I1114-YY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: TM-Beta1

Application*: BL, F, IF, IH, IP

Rat Anti-IL2RB Recombinant Antibody (CBYY-I0474) (CBMAB-I1113-YY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYY-I0474

Application*: F, IP, BL, N, FN, IH

Mouse Anti-IL2RB Recombinant Antibody (CBYY-I0334) (CBMAB-I0874-YY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I0334

Application*: F

Mouse Anti-IL2RB Recombinant Antibody (L316) (CBMAB-I0798-YY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: L316

Application*: F

Mouse Anti-IL2RB Recombinant Antibody (CBYY-I0204) (CBMAB-I0545-YY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0204

Application*: WB

Mouse Anti-IL2RB Recombinant Antibody (CBYY-I0203) (CBMAB-I0544-YY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0203

Application*: F, IH, N, MC

Rat Anti-IL2RB Recombinant Antibody (5K263) (CBMAB-C7797-LY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 5K263

Application*: F, IP

Rat Anti-IL2RB Recombinant Antibody (14L149) (CBMAB-C3095-LY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: 14L149

Application*: WB

Rat Anti-IL2RB Recombinant Antibody (10B674) (CBMAB-C2263-LY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 10B674

Application*: F, IP

Mouse Anti-IL2RB Recombinant Antibody (3H1832) (CBMAB-C1208-LY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 3H1832

Application*: F

Rat Anti-IL2RB Recombinant Antibody (A548) (CBMAB-AP15769LY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: A548

Application*: FC, IP

Rat Anti-IL2RB Recombinant Antibody (A547) (CBMAB-AP11965LY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: A547

Application*: FC, IP

Rabbit Anti-IL2RB Recombinant Antibody (D4X3H) (CBMAB-CP1164-LY)

SDS

Target: IL2RB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D4X3H

Application*: WB, IP

Mouse Anti-IL2RB Recombinant Antibody (MIK-Beta 1) (CBMAB-C11721-LY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: MIK-Beta 1

Application*: F

Mouse Anti-IL2RB Recombinant Antibody (TU27) (CBMAB-C11718-LY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: TU27

Application*: F

Rat Anti-IL2RB Recombinant Antibody (TM-b1 TM-beta1) (CBMAB-C11717-LY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: TM-b1 TM-beta1

Application*: F

Mouse Anti-IL2RB Recombinant Antibody (7H139) (CBMAB-C0360-CN)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 7H139

Application*: FC

Mouse Anti-IL2RB Recombinant Antibody (CBYY-C2571) (CBMAB-C4012-YY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C2571

Application*: F

Rat Anti-IL2RB Recombinant Antibody (CBYY-C0456) (CBMAB-C1412-YY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBYY-C0456

Application*: F, IP

Mouse Anti-IL2RB Recombinant Antibody (CBYY-C0153) (CBMAB-C0500-YY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBYY-C0153

Application*: F

Mouse Anti-IL2RB Recombinant Antibody (27302) (CBMAB-C4510-LY)

SDS

Target: IL2RB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 27302

Application*: F, IH, N

Rat Anti-IL2RB Recombinant Antibody (5H4) (CBMAB-0966-LY)

SDS

Target: IL2RB

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 5H4

Application*: IP, F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Go to
Compare