Sign in or Register   Sign in or Register
  |  

Rat Anti-IL2RB Recombinant Antibody (CBXC-1399) (CBMAB-C2629-CQ)

This product is a rat antibody that recognizes IL2RB. The antibody CBXC-1399 can be used for immunoassay techniques such as: FC, IP.
See all IL2RB antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1399
Antibody Isotype
IgG2b
Application
FC, IP

Basic Information

Immunogen
Cells from murine IL-2RB+ transformant TART-mBeta
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 2 Receptor Subunit Beta
Introduction
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.
Entrez Gene ID
16185
UniProt ID
P16297
Alternative Names
Interleukin 2 Receptor Subunit Beta
Function
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:MGI
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Involvement in disease
Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63):
An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease.
Topology
Extracellular: 27-240
Helical: 241-265
Cytoplasmic: 266-551

Liao, Y., Ke, B., Long, X., Xu, J., & Wu, Y. (2022). Upregulated expression of IL2RB causes disorder of immune microenvironment in patients with Kawasaki disease. BioMed Research International, 2022.

Li, G., Wang, Y., & Cheng, Y. (2022). IL2RB is a prognostic biomarker associated with immune infiltrates in pan-cancer. Journal of Oncology, 2022.

Cheng, C. C., Lin, H. C., Chiang, Y. W., Chang, J., Sie, Z. L., Yang, B. L., ... & Chang, Y. F. (2021). Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression. Cancer Immunology, Immunotherapy, 70, 1351-1364.

Alderdice, M., Craig, S. G., Humphries, M. P., Gilmore, A., Johnston, N., Bingham, V., ... & McArt, D. G. (2021). Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer. NAR genomics and bioinformatics, 3(2), lqab016.

Lou, W., Yan, J., & Wang, W. (2021). Downregulation of miR-497-5p improves sepsis-induced acute lung injury by targeting IL2RB. BioMed Research International, 2021.

Chen, X., Xingfan, W., Zaozhang, Z., Yuewu, C., & Wang, C. (2021). Role of IL-9, IL-2RA, and IL-2RB genetic polymorphisms in coronary heart disease. Herz, 46(6), 558-566.

Fernandez, I. Z., Baxter, R. M., Garcia-Perez, J. E., Vendrame, E., Ranganath, T., Kong, D. S., ... & Hsieh, E. W. (2019). A novel human IL2RB mutation results in T and NK cell–driven immune dysregulation. Journal of Experimental Medicine, 216(6), 1255-1267.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

Mei, L., Huang, C., Wang, A., & Zhang, X. (2019). Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population. International Immunopharmacology, 77, 105930.

Campbell, T. M., & Bryceson, Y. T. (2019). IL2RB maintains immune harmony. Journal of Experimental Medicine, 216(6), 1231-1233.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-IL2RB Recombinant Antibody (CBXC-1399)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare