Mouse Recombinant IL2RB protein, His Tag-1 (V2LY-0526-LY8528)

Name: Mouse Recombinant IL2RB protein, His Tag-1
SKU: V2LY-0526-LY8528
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant IL2RB protein, His Tag consist of Amino Acid: 1-240 and predicts a molecular mass of 26.5 kDa.

Molecule Mass

26.5 kDa

Verified

HPLC

Sequence

Amino Acid: 1-240

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC. ≥95% as determined by SEC-MALS(Routinely tested).

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 2 Receptor Subunit Beta

Alternative Names

Interleukin 2 Receptor Subunit Beta

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:MGI
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Involvement in disease

Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63):
An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease.

Topology

Extracellular: 27-240
Helical: 241-265
Cytoplasmic: 266-551

Liao, Y., Ke, B., Long, X., Xu, J., & Wu, Y. (2022). Upregulated expression of IL2RB causes disorder of immune microenvironment in patients with Kawasaki disease. BioMed Research International, 2022.

Li, G., Wang, Y., & Cheng, Y. (2022). IL2RB is a prognostic biomarker associated with immune infiltrates in pan-cancer. Journal of Oncology, 2022.

Cheng, C. C., Lin, H. C., Chiang, Y. W., Chang, J., Sie, Z. L., Yang, B. L., ... & Chang, Y. F. (2021). Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression. Cancer Immunology, Immunotherapy, 70, 1351-1364.

Alderdice, M., Craig, S. G., Humphries, M. P., Gilmore, A., Johnston, N., Bingham, V., ... & McArt, D. G. (2021). Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer. NAR genomics and bioinformatics, 3(2), lqab016.

Lou, W., Yan, J., & Wang, W. (2021). Downregulation of miR-497-5p improves sepsis-induced acute lung injury by targeting IL2RB. BioMed Research International, 2021.

Chen, X., Xingfan, W., Zaozhang, Z., Yuewu, C., & Wang, C. (2021). Role of IL-9, IL-2RA, and IL-2RB genetic polymorphisms in coronary heart disease. Herz, 46(6), 558-566.

Fernandez, I. Z., Baxter, R. M., Garcia-Perez, J. E., Vendrame, E., Ranganath, T., Kong, D. S., ... & Hsieh, E. W. (2019). A novel human IL2RB mutation results in T and NK cell–driven immune dysregulation. Journal of Experimental Medicine, 216(6), 1255-1267.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

Mei, L., Huang, C., Wang, A., & Zhang, X. (2019). Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population. International Immunopharmacology, 77, 105930.

Campbell, T. M., & Bryceson, Y. T. (2019). IL2RB maintains immune harmony. Journal of Experimental Medicine, 216(6), 1231-1233.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant CD122 protein, hFc Tag (CAT#: V2LY-0526-LY1283)

Canine Recombinant CD122 protein, His Tag (CAT#: V2LY-0526-LY1284)

Human Recombinant IL2RB protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4872)

Human Recombinant IL2RB protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4873)

Human Recombinant IL2RB protein, ECD, His Tag (CAT#: V2LY-0526-LY4874)

Human Recombinant IL2RB protein, ECD, Fc Tag (CAT#: V2LY-0526-LY4875)

Human Recombinant IL2RB protein, His Tag (CAT#: V2LY-0526-LY4876)

Human Recombinant IL2RB protein (CAT#: V2LY-0526-LY4877)

Human Recombinant IL2RB & IL2RG protein, Dimer, Biotin Conjugated, AVI Tag (CAT#: V2LY-0526-LY4884)

Mouse Recombinant IL2RB protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8526)

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Isotype control

For research use only. Not intended for any clinical use.

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