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Rabbit Anti-IL2RB Recombinant Antibody (D4X3H) (CBMAB-CP1164-LY)

The product is antibody recognizes IL2RB. The antibody D4X3H immunoassay techniques such as: WB,IP.
See all IL2RB antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D4X3H
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu428 of human IL-2Rβ protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 2 Receptor Subunit Beta
Introduction
IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Entrez Gene ID
3560
UniProt ID
P14784
Alternative Names
Interleukin 20 Receptor Subunit Beta
Function
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Interleukin-2-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:MGI
Positive regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Involvement in disease
Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63):
An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease.
Topology
Extracellular: 27-240
Helical: 241-265
Cytoplasmic: 266-551

Liao, Y., Ke, B., Long, X., Xu, J., & Wu, Y. (2022). Upregulated expression of IL2RB causes disorder of immune microenvironment in patients with Kawasaki disease. BioMed Research International, 2022.

Li, G., Wang, Y., & Cheng, Y. (2022). IL2RB is a prognostic biomarker associated with immune infiltrates in pan-cancer. Journal of Oncology, 2022.

Cheng, C. C., Lin, H. C., Chiang, Y. W., Chang, J., Sie, Z. L., Yang, B. L., ... & Chang, Y. F. (2021). Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression. Cancer Immunology, Immunotherapy, 70, 1351-1364.

Alderdice, M., Craig, S. G., Humphries, M. P., Gilmore, A., Johnston, N., Bingham, V., ... & McArt, D. G. (2021). Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer. NAR genomics and bioinformatics, 3(2), lqab016.

Lou, W., Yan, J., & Wang, W. (2021). Downregulation of miR-497-5p improves sepsis-induced acute lung injury by targeting IL2RB. BioMed Research International, 2021.

Chen, X., Xingfan, W., Zaozhang, Z., Yuewu, C., & Wang, C. (2021). Role of IL-9, IL-2RA, and IL-2RB genetic polymorphisms in coronary heart disease. Herz, 46(6), 558-566.

Fernandez, I. Z., Baxter, R. M., Garcia-Perez, J. E., Vendrame, E., Ranganath, T., Kong, D. S., ... & Hsieh, E. W. (2019). A novel human IL2RB mutation results in T and NK cell–driven immune dysregulation. Journal of Experimental Medicine, 216(6), 1255-1267.

Jia, Z., Zhang, Z., Yang, Q., Deng, C., Li, D., & Ren, L. (2019). Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk. International immunopharmacology, 74, 105716.

Mei, L., Huang, C., Wang, A., & Zhang, X. (2019). Association between ADRB2, IL33, and IL2RB gene polymorphisms and lung cancer risk in a Chinese Han population. International Immunopharmacology, 77, 105930.

Campbell, T. M., & Bryceson, Y. T. (2019). IL2RB maintains immune harmony. Journal of Experimental Medicine, 216(6), 1231-1233.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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