Sign in or Register   Sign in or Register
  |  

Mouse Anti-IL3 Recombinant Antibody (CBYY-I2023) (CBMAB-I3193-YY)

This product is Mouse antibody that recognizes IL3. The antibody CBYY-I2023 can be used for immunoassay techniques such as: WB, IHC, IF
See all IL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I2023
Antibody Isotype
IgG1
Application
WB, IHC, IF

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 20-152 of human IL-3 (NP_000579)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.39 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 3
Introduction
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
Entrez Gene ID
3562
UniProt ID
P08700
Alternative Names
Interleukin 3
Function
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Embryonic hemopoiesisManual Assertion Based On ExperimentIDA:DFLAT
Immune responseIEA:InterPro
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Secreted

Wang, H., Tumes, D. J., Hercus, T. R., Yip, K. H., Aloe, C., Vlahos, R., ... & Bozinovski, S. (2022). Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death & Disease, 13(2), 137.

Rani, L., Kumar, A., Karhade, J., Pandey, G., Guha, A., Mishra, G. C., & Wani, M. R. (2022). IL‐3 regulates the differentiation of pathogenic Th17 cells. European Journal of Immunology, 52(11), 1842-1858.

Varricchi, G., Poto, R., Marone, G., & Schroeder, J. T. (2021, April). IL-3 in the development and function of basophils. In Seminars in immunology (Vol. 54, p. 101510). Academic Press.

Aldoss, I., Clark, M., Song, J. Y., & Pullarkat, V. (2020). Targeting the alpha subunit of IL-3 receptor (CD123) in patients with acute leukemia. Human vaccines & immunotherapeutics, 16(10), 2341-2348.

Tong, Y., Lear, T. B., Evankovich, J., Chen, Y., Londino, J. D., Myerburg, M. M., ... & Chen, B. B. (2020). The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity. JCI insight, 5(3).

Kumar, A., Rani, L., Mhaske, S. T., Pote, S. T., Behera, S., Mishra, G. C., & Wani, M. R. (2020). IL-3 receptor expression on activated human Th cells is regulated by IL-4, and IL-3 synergizes with IL-4 to enhance Th2 cell differentiation. The Journal of Immunology, 204(4), 819-831.

Dougan, M., Dranoff, G., & Dougan, S. K. (2019). GM-CSF, IL-3, and IL-5 family of cytokines: regulators of inflammation. Immunity, 50(4), 796-811.

Borriello, F., Galdiero, M. R., Varricchi, G., Loffredo, S., Spadaro, G., & Marone, G. (2019). Innate immune modulation by GM-CSF and IL-3 in health and disease. International journal of molecular sciences, 20(4), 834.

Zaidi, N., Quezada, S. A., Kuroiwa, J. M., Zhang, L., Jaffee, E. M., Steinman, R. M., & Wang, B. (2019). Anti–CTLA‐4 synergizes with dendritic cell–targeted vaccine to promote IL‐3–dependent CD4+ effector T cell infiltration into murine pancreatic tumors. Annals of the New York Academy of Sciences, 1445(1), 62-73.

Broughton, S. E., Hercus, T. R., Nero, T. L., Kan, W. L., Barry, E. F., Dottore, M., ... & Parker, M. W. (2018). A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nature communications, 9(1), 386.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IL3 Recombinant Antibody (CBYY-I2023)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare