Mouse Anti-IL4R Recombinant Antibody (CBYY-I0964) (CBMAB-I2132-YY)

Name: Mouse Anti-IL4R Recombinant Antibody (CBYY-I0964)
SKU: CBMAB-I2132-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I0964

Application

IHC, Neut, WB

Specificity

Human

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

0.2μm filtered solution in PBS

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interleukin 4 Receptor

Introduction

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

3566

UniProt ID

P24394

Alternative Names

Interleukin 4 Receptor

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.1 Publication
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Biological Process

Defense response to protozoanIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Immunoglobulin mediated immune responseIEA:Ensembl
Negative regulation of T-helper 1 cell differentiationIEA:Ensembl
OvulationIEA:Ensembl
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of immunoglobulin productionIEA:Ensembl
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of mast cell degranulationIEA:Ensembl
Positive regulation of myoblast fusionIEA:Ensembl
Positive regulation of T-helper 2 cell differentiationIEA:Ensembl
Production of molecular mediator involved in inflammatory responseIEA:InterPro
Regulation of cell population proliferationIEA:Ensembl
Response to estrogenIEA:Ensembl
Response to odorantIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Isoform 2: Secreted

Topology

Extracellular: 26-232
Helical: 233-256
Cytoplasmic: 257-825

PTM

On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Aranda, C. J., Gonzalez‐Kozlova, E., Saunders, S. P., Fernandes‐Braga, W., Ota, M., Narayanan, S., ... & Curotto de Lafaille, M. A. (2023). IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy, 78(3), 752-766.

Forman, R., Logunova, L., Smith, H., Wemyss, K., Mair, I., Boon, L., ... & Else, K. J. (2021). Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages. PLoS Pathogens, 17(7), e1009768.

Ellingson, B. M., Sampson, J., Achrol, A. S., Aghi, M. K., Bankiewicz, K., Wang, C., ... & Merchant, F. (2021). Modified RANO, immunotherapy RANO, and standard RANO response to convection-enhanced delivery of IL4R-targeted immunotoxin MDNA55 in recurrent glioblastoma. Clinical Cancer Research, 27(14), 3916-3925.

Jin, Q., Yang, H., Jing, Z., Hong-Hua, W., Ben-Jing, S., Li-Ting, W., ... & Wei, Z. (2021). IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors. Molecular Medicine, 27(1), 1-13.

Muhammad, S. B., Hassan, F., Bhowmik, K. K., Millat, M. S., Sarwar, M. S., Aziz, M. A., ... & Islam, M. S. (2021). Detection of association of IL1β, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method. International Immunopharmacology, 90, 107131.

Sampson, J. H., Achrol, A., Aghi, M. K., Bankiewicz, K., Bexon, M., Brem, S., ... & Butowski, N. A. (2020). MDNA55 survival in recurrent glioblastoma (rGBM) patients expressing the interleukin-4 receptor (IL4R) as compared to a matched synthetic control.

Amano, Y., Akazawa, Y., Yasuda, J., Yoshino, K., Kojima, K., Kobayashi, N., ... & Takeshita, T. (2019). A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease. Pediatric Rheumatology, 17(1), 1-11.

Ziyab, A. H., Hankinson, J., Ewart, S., Schauberger, E., Kopec-Harding, K., Zhang, H., ... & Karmaus, W. J. (2018). Epistasis between FLG and IL4R genes on the risk of allergic sensitization: results from two population-based birth cohort studies. Scientific Reports, 8(1), 3221.

Viganò, E., Gunawardana, J., Mottok, A., Van Tol, T., Mak, K., Chan, F. C., ... & Steidl, C. (2018). Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation. Blood, The Journal of the American Society of Hematology, 131(18), 2036-2046.

Lai, P. S., Massoud, A. H., Xia, M., Petty, C. R., Cunningham, A., Chatila, T. A., & Phipatanakul, W. (2018). Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children. Journal of Allergy and Clinical Immunology, 141(2), 794-796.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

IL4R Matched Antibody Pair (635) (CAT#: APMAB-635LY)

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For research use only. Not intended for any clinical use.

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