IL4R Matched Antibody Pair (635) (APMAB-635LY)

Name: IL4R Matched Antibody Pair (635)
SKU: APMAB-635LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-IL4R monoclonal, IgG2a antibody, 100 ug

Detection Antibody

Anti-IL4R Biotinylated mouse monoclonal, IgG2a antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Alternative Names

Interleukin 4 Receptor

Entrez Gene ID

3566

UniProt ID

P24394

More Infomation

Aranda, C. J., Gonzalez‐Kozlova, E., Saunders, S. P., Fernandes‐Braga, W., Ota, M., Narayanan, S., ... & Curotto de Lafaille, M. A. (2023). IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy, 78(3), 752-766.

Forman, R., Logunova, L., Smith, H., Wemyss, K., Mair, I., Boon, L., ... & Else, K. J. (2021). Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages. PLoS Pathogens, 17(7), e1009768.

Ellingson, B. M., Sampson, J., Achrol, A. S., Aghi, M. K., Bankiewicz, K., Wang, C., ... & Merchant, F. (2021). Modified RANO, immunotherapy RANO, and standard RANO response to convection-enhanced delivery of IL4R-targeted immunotoxin MDNA55 in recurrent glioblastoma. Clinical Cancer Research, 27(14), 3916-3925.

Jin, Q., Yang, H., Jing, Z., Hong-Hua, W., Ben-Jing, S., Li-Ting, W., ... & Wei, Z. (2021). IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors. Molecular Medicine, 27(1), 1-13.

Muhammad, S. B., Hassan, F., Bhowmik, K. K., Millat, M. S., Sarwar, M. S., Aziz, M. A., ... & Islam, M. S. (2021). Detection of association of IL1β, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method. International Immunopharmacology, 90, 107131.

Sampson, J. H., Achrol, A., Aghi, M. K., Bankiewicz, K., Bexon, M., Brem, S., ... & Butowski, N. A. (2020). MDNA55 survival in recurrent glioblastoma (rGBM) patients expressing the interleukin-4 receptor (IL4R) as compared to a matched synthetic control.

Amano, Y., Akazawa, Y., Yasuda, J., Yoshino, K., Kojima, K., Kobayashi, N., ... & Takeshita, T. (2019). A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease. Pediatric Rheumatology, 17(1), 1-11.

Ziyab, A. H., Hankinson, J., Ewart, S., Schauberger, E., Kopec-Harding, K., Zhang, H., ... & Karmaus, W. J. (2018). Epistasis between FLG and IL4R genes on the risk of allergic sensitization: results from two population-based birth cohort studies. Scientific Reports, 8(1), 3221.

Viganò, E., Gunawardana, J., Mottok, A., Van Tol, T., Mak, K., Chan, F. C., ... & Steidl, C. (2018). Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation. Blood, The Journal of the American Society of Hematology, 131(18), 2036-2046.

Lai, P. S., Massoud, A. H., Xia, M., Petty, C. R., Cunningham, A., Chatila, T. A., & Phipatanakul, W. (2018). Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children. Journal of Allergy and Clinical Immunology, 141(2), 794-796.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL4R & IL2RG protein, Hetero Dimer , His Tag (CAT#: V2LY-0526-LY4926)

Cynomolgus Recombinant IL4R protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1575)

Cynomolgus Recombinant IL4R protein, His Tag (CAT#: V2LY-0526-LY1576)

Cynomolgus Recombinant IL4R protein, His Tag-1 (CAT#: V2LY-0526-LY1577)

Human Recombinant IL4R protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4927)

Human Recombinant IL4R protein, ECD, His Tag (CAT#: V2LY-0526-LY4928)

Human Recombinant IL4R protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY4929)

Human Recombinant IL4R protein, hFc Tag (CAT#: V2LY-0526-LY4930)

Human Recombinant IL4R protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4931)

Human Recombinant IL4R & IL13RA1 protein, Hetero Dimer , hFc Tag (CAT#: V2LY-0526-LY4932)

Related Products

Mouse Anti-IL4R Recombinant Antibody (CBYY-C1160) (CAT#: CBMAB-C2597-YY)

Cynomolgus Recombinant IL4R protein, His Tag (CAT#: V2LY-0526-LY1576)

Human Recombinant IL4R & IL13RA1 protein, Hetero Dimer , hFc Tag (CAT#: V2LY-0526-LY4932)

Rabbit Anti-IL4R Recombinant Antibody (CBFYC-2773) (CAT#: CBMAB-C2849-FY)

Mouse Anti-IL4R Recombinant Antibody (CBWJC-3832) (CAT#: CBMAB-C5103WJ)

Human Recombinant IL4R protein, ECD, His Tag (CAT#: V2LY-0526-LY4928)

Rat Anti-IL4R Recombinant Antibody (CBWJC-3834) (CAT#: CBMAB-C5105WJ)

Rat Recombinant IL4R protein, His Tag (CAT#: V2LY-0526-LY9480)

Mouse Anti-IL4R Recombinant Antibody (CBWJC-2200) (CAT#: CBMAB-C2986WJ)

Rabbit Anti-IL4R Recombinant Antibody (209) (CAT#: CBMAB-I0588-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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