Human Recombinant IL4R & IL13RA1 protein, Hetero Dimer , hFc Tag (V2LY-0526-LY4932)

Name: Human Recombinant IL4R & IL13RA1 protein, Hetero Dimer , hFc Tag
SKU: V2LY-0526-LY4932
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant IL4R & IL13RA1 protein, Hetero Dimer , hFc Tag consist of Amino Acid: 26-232, 22-343 and predicts a molecular mass of 115.2 kDa.

Molecule Mass

115.2 kDa

Polymeric

Hetero Dimer

Verified

HPLC

Sequence

Amino Acid: 26-232, 22-343

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 4 Receptor

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.1 Publication
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Biological Process

Defense response to protozoanIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Immunoglobulin mediated immune responseIEA:Ensembl
Negative regulation of T-helper 1 cell differentiationIEA:Ensembl
OvulationIEA:Ensembl
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of immunoglobulin productionIEA:Ensembl
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of mast cell degranulationIEA:Ensembl
Positive regulation of myoblast fusionIEA:Ensembl
Positive regulation of T-helper 2 cell differentiationIEA:Ensembl
Production of molecular mediator involved in inflammatory responseIEA:InterPro
Regulation of cell population proliferationIEA:Ensembl
Response to estrogenIEA:Ensembl
Response to odorantIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Isoform 2: Secreted

Topology

Extracellular: 26-232
Helical: 233-256
Cytoplasmic: 257-825

PTM

On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Aranda, C. J., Gonzalez‐Kozlova, E., Saunders, S. P., Fernandes‐Braga, W., Ota, M., Narayanan, S., ... & Curotto de Lafaille, M. A. (2023). IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy, 78(3), 752-766.

Forman, R., Logunova, L., Smith, H., Wemyss, K., Mair, I., Boon, L., ... & Else, K. J. (2021). Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages. PLoS Pathogens, 17(7), e1009768.

Ellingson, B. M., Sampson, J., Achrol, A. S., Aghi, M. K., Bankiewicz, K., Wang, C., ... & Merchant, F. (2021). Modified RANO, immunotherapy RANO, and standard RANO response to convection-enhanced delivery of IL4R-targeted immunotoxin MDNA55 in recurrent glioblastoma. Clinical Cancer Research, 27(14), 3916-3925.

Jin, Q., Yang, H., Jing, Z., Hong-Hua, W., Ben-Jing, S., Li-Ting, W., ... & Wei, Z. (2021). IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors. Molecular Medicine, 27(1), 1-13.

Muhammad, S. B., Hassan, F., Bhowmik, K. K., Millat, M. S., Sarwar, M. S., Aziz, M. A., ... & Islam, M. S. (2021). Detection of association of IL1β, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method. International Immunopharmacology, 90, 107131.

Sampson, J. H., Achrol, A., Aghi, M. K., Bankiewicz, K., Bexon, M., Brem, S., ... & Butowski, N. A. (2020). MDNA55 survival in recurrent glioblastoma (rGBM) patients expressing the interleukin-4 receptor (IL4R) as compared to a matched synthetic control.

Amano, Y., Akazawa, Y., Yasuda, J., Yoshino, K., Kojima, K., Kobayashi, N., ... & Takeshita, T. (2019). A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease. Pediatric Rheumatology, 17(1), 1-11.

Ziyab, A. H., Hankinson, J., Ewart, S., Schauberger, E., Kopec-Harding, K., Zhang, H., ... & Karmaus, W. J. (2018). Epistasis between FLG and IL4R genes on the risk of allergic sensitization: results from two population-based birth cohort studies. Scientific Reports, 8(1), 3221.

Viganò, E., Gunawardana, J., Mottok, A., Van Tol, T., Mak, K., Chan, F. C., ... & Steidl, C. (2018). Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation. Blood, The Journal of the American Society of Hematology, 131(18), 2036-2046.

Lai, P. S., Massoud, A. H., Xia, M., Petty, C. R., Cunningham, A., Chatila, T. A., & Phipatanakul, W. (2018). Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children. Journal of Allergy and Clinical Immunology, 141(2), 794-796.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL4R & IL2RG protein, Hetero Dimer , His Tag (CAT#: V2LY-0526-LY4926)

Cynomolgus Recombinant IL4R protein, ECD, hFc Tag (CAT#: V2LY-0526-LY1575)

Cynomolgus Recombinant IL4R protein, His Tag (CAT#: V2LY-0526-LY1576)

Cynomolgus Recombinant IL4R protein, His Tag-1 (CAT#: V2LY-0526-LY1577)

Human Recombinant IL4R protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4927)

Human Recombinant IL4R protein, ECD, His Tag (CAT#: V2LY-0526-LY4928)

Human Recombinant IL4R protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY4929)

Human Recombinant IL4R protein, hFc Tag (CAT#: V2LY-0526-LY4930)

Human Recombinant IL4R protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4931)

Mouse Recombinant IL4R protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8547)

Antibody Pairs

IL4R Matched Antibody Pair (635) (CAT#: APMAB-635LY)

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Mouse Recombinant IL4R protein, ECD, His Tag (CAT#: V2LY-0526-LY8548)

Rat Recombinant IL4R protein, hFc Tag (CAT#: V2LY-0526-LY9479)

Human Recombinant IL4R protein, ECD, His Tag (CAT#: V2LY-0526-LY4928)

Human Recombinant IL4R protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4927)

Human Recombinant IL4R protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY4931)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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