Mouse Anti-IL6 Recombinant Antibody (A587) (CBMAB-AP3971LY)

Mouse

Human

A587

IgG

ICC, IHC, IP, WB

Pro29~Met212

Human

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

Affinity purity

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Interleukin 6

MAA079Hu22

Acute-phase responseManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:MGI
Cellular response to virusISS:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentTAS:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentTAS:BHF-UCL
Defense response to virusManual Assertion Based On ExperimentIDA:BHF-UCL
Endocrine pancreas developmentISS:BHF-UCL
Germinal center B cell differentiationISS:UniProtKB
Glucagon secretionISS:BHF-UCL
Glucose homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Hepatic immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Hepatocyte proliferationISS:UniProtKB
Humoral immune response1 PublicationIC:BHF-UCL
Inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Interleukin-6-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Liver regenerationISS:UniProtKB
Maintenance of blood-brain barrierManual Assertion Based On ExperimentTAS:ARUK-UCL
Monocyte chemotaxis1 PublicationIC:BHF-UCL
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of bone resorptionISS:BHF-UCL
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of chemokine productionISS:UniProtKB
Negative regulation of collagen biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of fat cell differentiation1 PublicationNAS:BHF-UCL
Negative regulation of interleukin-1-mediated signaling pathwayISS:BHF-UCL
Negative regulation of lipid storage1 PublicationNAS:BHF-UCL
Negative regulation of neurogenesisManual Assertion Based On ExperimentTAS:ARUK-UCL
Negative regulation of primary miRNA processingManual Assertion Based On ExperimentIGI:ARUK-UCL
Neuron cellular homeostasisManual Assertion Based On ExperimentTAS:ARUK-UCL
Neuron projection developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Neutrophil apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil mediated immunityManual Assertion Based On ExperimentTAS:BHF-UCL
Platelet activationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of acute inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of apoptotic DNA fragmentationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of B cell activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of chemokine productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of extracellular matrix disassemblyManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of glial cell proliferationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of immunoglobulin productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of interleukin-17 productionBy SimilarityISS:ARUK-UCL
Positive regulation of interleukin-21 productionISS:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of leukocyte adhesion to vascular endothelial cellManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of leukocyte chemotaxisManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neuroinflammatory responseManual Assertion Based On ExperimentTAS:ARUK-UCL
Positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of platelet aggregationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of production of miRNAs involved in gene silencing by miRNAManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor signaling pathway via STATManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T-helper 2 cell cytokine productionISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of translationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of type B pancreatic cell apoptotic processManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of vascular endothelial growth factor productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of angiogenesis1 PublicationIC:BHF-UCL
Regulation of astrocyte activationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of glucagon secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of insulin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of microglial cell activationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of neuroinflammatory responseManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of vascular endothelial growth factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to activityISS:UniProtKB
Response to glucocorticoidManual Assertion Based On ExperimentIDA:BHF-UCL
Response to peptidoglycan1 PublicationNAS:BHF-UCL
T follicular helper cell differentiationISS:UniProtKB
T-helper 17 cell lineage commitmentISS:UniProtKB
Vascular endothelial growth factor productionManual Assertion Based On ExperimentIDA:UniProtKB

Secreted

Rheumatoid arthritis systemic juvenile (RASJ):
An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

N- and O-glycosylated.