Mouse Anti-IL6 Recombinant Antibody (A587) (CBMAB-AP3971LY)

Name: Mouse Anti-IL6 Recombinant Antibody (A587)
SKU: CBMAB-AP3971LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A587

Application

ICC, IHC, IP, WB

Immunogen

Pro29~Met212

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 6

Introduction

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Entrez Gene ID

3569

UniProt ID

P05231

Alternative Names

Interleukin 6

Function

MAA079Hu22

Biological Process

Acute-phase responseManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:MGI
Cellular response to virusISS:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentTAS:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentTAS:BHF-UCL
Defense response to virusManual Assertion Based On ExperimentIDA:BHF-UCL
Endocrine pancreas developmentISS:BHF-UCL
Germinal center B cell differentiationISS:UniProtKB
Glucagon secretionISS:BHF-UCL
Glucose homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Hepatic immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Hepatocyte proliferationISS:UniProtKB
Humoral immune response1 PublicationIC:BHF-UCL
Inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Interleukin-6-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Liver regenerationISS:UniProtKB
Maintenance of blood-brain barrierManual Assertion Based On ExperimentTAS:ARUK-UCL
Monocyte chemotaxis1 PublicationIC:BHF-UCL
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of bone resorptionISS:BHF-UCL
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of chemokine productionISS:UniProtKB
Negative regulation of collagen biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of fat cell differentiation1 PublicationNAS:BHF-UCL
Negative regulation of interleukin-1-mediated signaling pathwayISS:BHF-UCL
Negative regulation of lipid storage1 PublicationNAS:BHF-UCL
Negative regulation of neurogenesisManual Assertion Based On ExperimentTAS:ARUK-UCL
Negative regulation of primary miRNA processingManual Assertion Based On ExperimentIGI:ARUK-UCL
Neuron cellular homeostasisManual Assertion Based On ExperimentTAS:ARUK-UCL
Neuron projection developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Neutrophil apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Neutrophil mediated immunityManual Assertion Based On ExperimentTAS:BHF-UCL
Platelet activationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of acute inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of apoptotic DNA fragmentationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of B cell activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of chemokine productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of extracellular matrix disassemblyManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of glial cell proliferationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of immunoglobulin productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of interleukin-17 productionBy SimilarityISS:ARUK-UCL
Positive regulation of interleukin-21 productionISS:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of leukocyte adhesion to vascular endothelial cellManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of leukocyte chemotaxisManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neuroinflammatory responseManual Assertion Based On ExperimentTAS:ARUK-UCL
Positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of platelet aggregationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of production of miRNAs involved in gene silencing by miRNAManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor signaling pathway via STATManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T-helper 2 cell cytokine productionISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of translationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of type B pancreatic cell apoptotic processManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of vascular endothelial growth factor productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of angiogenesis1 PublicationIC:BHF-UCL
Regulation of astrocyte activationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of glucagon secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of insulin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of microglial cell activationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of neuroinflammatory responseManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of vascular endothelial growth factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Response to activityISS:UniProtKB
Response to glucocorticoidManual Assertion Based On ExperimentIDA:BHF-UCL
Response to peptidoglycan1 PublicationNAS:BHF-UCL
T follicular helper cell differentiationISS:UniProtKB
T-helper 17 cell lineage commitmentISS:UniProtKB
Vascular endothelial growth factor productionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted

Involvement in disease

Rheumatoid arthritis systemic juvenile (RASJ):
An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

PTM

N- and O-glycosylated.

McAndrews, K. M., Chen, Y., Darpolor, J. K., Zheng, X., Yang, S., Carstens, J. L., ... & Kalluri, R. (2022). Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer. Cancer discovery, 12(6), 1580-1597.

Martínez-Pérez, C., Kay, C., Meehan, J., Gray, M., Dixon, J. M., & Turnbull, A. K. (2021). The IL6-like cytokine family: Role and biomarker potential in breast cancer. Journal of personalized medicine, 11(11), 1073.

Jing, B., Wang, T., Sun, B., Xu, J., Xu, D., Liao, Y., ... & Deng, J. (2020). IL6/STAT3 signaling orchestrates premetastatic niche formation and immunosuppressive traits in lung. Cancer research, 80(4), 784-797.

Siersbæk, R., Scabia, V., Nagarajan, S., Chernukhin, I., Papachristou, E. K., Broome, R., ... & Carroll, J. S. (2020). IL6/STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis. Cancer Cell, 38(3), 412-423.

Rossotti, R., Travi, G., Ughi, N., Corradin, M., Baiguera, C., Fumagalli, R., ... & Niguarda COVID-19 Working Group. (2020). Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: A comparative analysis. Journal of Infection, 81(4), e11-e17.

Rosa, M., Chignon, A., Li, Z., Boulanger, M. C., Arsenault, B. J., Bossé, Y., ... & Mathieu, P. (2019). A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity. NPJ genomic medicine, 4(1), 23.

Qiao, Y., Zhang, C., Li, A., Wang, D., Luo, Z., Ping, Y., ... & Zhang, Y. (2018). IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma. Oncogene, 37(7), 873-883.

Cheng, Y., Li, H., Deng, Y., Tai, Y., Zeng, K., Zhang, Y., ... & Yang, Y. (2018). Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. Cell death & disease, 9(4), 422.

Kato, T., Noma, K., Ohara, T., Kashima, H., Katsura, Y., Sato, H., ... & Fujiwara, T. (2018). Cancer-associated fibroblasts affect intratumoral CD8+ and FoxP3+ T cells via IL6 in the tumor microenvironment. Clinical Cancer Research, 24(19), 4820-4833.

Tsukamoto, H., Fujieda, K., Miyashita, A., Fukushima, S., Ikeda, T., Kubo, Y., ... & Oshiumi, H. (2018). Combined blockade of IL6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment. Cancer research, 78(17), 5011-5022.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

IL6 Matched Antibody Pair (636) (CAT#: APMAB-636LY)

IL6 Matched Antibody Pair (637) (CAT#: APMAB-637LY)

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For research use only. Not intended for any clinical use.

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