Mouse Anti-INHBB Recombinant Antibody (14L8) (CBMAB-A4495-YC)

Name: Mouse Anti-INHBB Recombinant Antibody (14L8)
SKU: CBMAB-A4495-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

14L8

Application

Neut, WB

Immunogen

Recombinant protein corresponding to human Activin B

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Inhibin Beta B Subunit

Introduction

INHBB is a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and in

Entrez Gene ID

3625

UniProt ID

P09529

Alternative Names

Inhibin Beta B Subunit

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Biological Process

Activin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cellular response to calcium ionIEA:Ensembl
Cellular response to cAMPIEA:Ensembl
Cellular response to cholesterolIEA:Ensembl
Cellular response to insulin stimulusISS:UniProtKB
Cellular response to interleukin-1IEA:Ensembl
Cellular response to leptin stimulusIEA:Ensembl
Cellular response to starvationISS:UniProtKB
Cellular response to Thyroglobulin triiodothyronineIEA:Ensembl
Cellular response to thyroid hormone stimulusIEA:Ensembl
Defense responseManual Assertion Based On ExperimentTAS:UniProtKB
Fat cell differentiationISS:UniProtKB
Negative regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIPI:UniProtKB
Negative regulation of hepatocyte growth factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of insulin secretionISS:UniProtKB
Oocyte developmentIEA:Ensembl
Ovarian follicle development1 PublicationNAS:UniProtKB
Pituitary gland developmentIEA:Ensembl
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIPI:UniProtKB
Positive regulation of ovulationISS:UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Reproductive senescenceIEA:Ensembl
Response to gonadotropinIEA:Ensembl
Response to insecticideIEA:Ensembl
Response to woundingManual Assertion Based On ExperimentIEP:UniProtKB
Seminiferous tubule developmentIEA:Ensembl
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
SpermatogenesisIEA:Ensembl

Cellular Location

Secreted

Zhang, H., Wang, Z., Zhou, Q., Cao, Z., Jiang, Y., Xu, M., ... & Sun, H. (2023). Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway. Journal of Assisted Reproduction and Genetics, 1-12.

Yang, X., Jia, Q., Zou, Z., Liu, X., Li, X., Chen, H., ... & Chen, L. (2023). INHBB promotes tumor aggressiveness and stemness of glioblastoma via activating EGFR signaling. Pathology-Research and Practice, 245, 154460.

Zhang, H., Zhang, X., & Wang, Z. (2023). P-517 Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway. Human Reproduction, 38(Supplement_1), dead093-860.

Sun, Y., Cai, H., Ge, J., Shao, F., Huang, Z., Ding, Z., ... & Zang, Y. (2022). Tubule‐derived INHBB promotes interstitial fibroblast activation and renal fibrosis. The Journal of pathology, 256(1), 25-37.

Houston, B. J., O’Connor, A. E., Wang, D., Goodchild, G., Merriner, D. J., Luan, H., ... & Walton, K. (2022). Human INHBB gene variant (c. 1079T> C: p. Met360Thr) alters testis germ cell content, but does not impact fertility in mice. Endocrinology, 163(3), bqab269.

Yu, W., He, G., Zhang, W., Ye, Z., Zhong, Z., & Huang, S. (2022). INHBB is a novel prognostic biomarker and correlated with immune infiltrates in gastric cancer. Frontiers in Genetics, 13, 933862.

Chen, Y., Qian, B., Sun, X., Kang, Z., Huang, Z., Ding, Z., ... & Zang, Y. (2021). Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma. Cancer letters, 499, 243-254.

Damavandi, M., Farrokh, P., & Zavareh, S. (2021). Effect of mouse ovarian vitrification on promoter methylation of inhba and inhbb in granulosa cells of follicles. Cryoletters, 42(2), 67-72.

Yuan, J., Xie, A., Cao, Q., Li, X., & Chen, J. (2020). INHBB is a novel prognostic biomarker associated with cancer-promoting pathways in colorectal cancer. BioMed research international, 2020.

Zheng, L., Lu, H., Li, H., Xu, X., & Wang, D. (2020). KLF10 is upregulated in osteoarthritis and inhibits chondrocyte proliferation and migration by upregulating Acvr1 and suppressing inhbb expression. Acta histochemica, 122(3), 151528.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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