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Rabbit Anti-INPP4B Recombinant Antibody (CBYY-I1697) (CBMAB-I2867-YY)

This product is Rabbit antibody that recognizes INPP4B. The antibody CBYY-I1697 can be used for immunoassay techniques such as: WB, IP, IHC-P
See all INPP4B antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-I1697
Application
WB, IP, IHC-P

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inositol Polyphosphate-4-Phosphatase Type II B
Introduction
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.
Entrez Gene ID
8821
UniProt ID
O15327
Alternative Names
Inositol Polyphosphate-4-Phosphatase Type II B
Function
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580).
Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580).
The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).
Biological Process
Inositol phosphate dephosphorylationIEA:Ensembl
Inositol phosphate metabolic processTAS:Reactome
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol dephosphorylationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm; Cytosol

Hu, T., Zhang, H., Du, Y., Luo, S., Yang, X., Zhang, H., ... & Zhang, Y. (2022). ELOVL2 restrains cell proliferation, migration, and invasion of prostate cancer via regulation of the tumor suppressor INPP4B. Cellular Signalling, 96, 110373.

Sun, X., Chen, Y., Tao, X., Zhang, W., Wang, X., Wang, X., ... & Chen, Z. (2022). INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway. Frontiers in Oncology, 12, 983537.

Zhang, M., Ceyhan, Y., Kaftanovskaya, E. M., Vasquez, J. L., Vacher, J., Knop, F. K., ... & Agoulnik, I. U. (2021). INPP4B protects from metabolic syndrome and associated disorders. Communications biology, 4(1), 416.

Hamila, S. A., Ooms, L. M., Rodgers, S. J., & Mitchell, C. A. (2021). The INPP4B paradox: like PTEN, but different. Advances in biological regulation, 82, 100817.

Wu, Y., Wang, X., Lu, Y., Wang, H., Wang, M., You, Y., ... & Li, Y. (2021). INPP4B exerts a dual role in gastric cancer progression and prognosis. Journal of Cancer, 12(23), 7201.

Rodgers, S. J., Ooms, L. M., Oorschot, V. M., Schittenhelm, R. B., Nguyen, E. V., Hamila, S. A., ... & Mitchell, C. A. (2021). INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer. Nature communications, 12(1), 3140.

Liu, H., Paddock, M. N., Wang, H., Murphy, C. J., Geck, R. C., Navarro, A. J., ... & Toker, A. (2020). The INPP4B tumor suppressor modulates EGFR trafficking and promotes triple-negative breast cancer. Cancer discovery, 10(8), 1226-1239.

Zhang, F., Li, J., Zhu, J., Liu, L., Zhu, K., Cheng, S., ... & Zhang, P. (2019). IRF2–INPP4B-mediated autophagy suppresses apoptosis in acute myeloid leukemia cells. Biological research, 52(1), 1-10.

Tang, W., Yang, L., Yang, T., Liu, M., Zhou, Y., Lin, J., ... & Ding, C. (2019). INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma. OncoTargets and therapy, 12, 3491.

Jin, H., Yang, L., Wang, L., Yang, Z., Zhan, Q., Tao, Y., ... & Zhang, L. (2018). INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia. Journal of Experimental & Clinical Cancer Research, 37, 1-15.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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