INPP4B

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Full Name
Inositol Polyphosphate-4-Phosphatase Type II B
Function
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580).
Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580).
The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).
Biological Process
Inositol phosphate dephosphorylationIEA:Ensembl
Inositol phosphate metabolic processTAS:Reactome
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol dephosphorylationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm; Cytosol
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Anti-INPP4B antibodies

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Rabbit Anti-INPP4B Recombinant Antibody (D19B9) (CBMAB-CP1177-LY)

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Target: INPP4B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D19B9
Application*: WB, IP
Datasheet SDS

Mouse Anti-INPP4B Recombinant Antibody (3F2) (CBMAB-A4487-LY)

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Target: INPP4B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F2
Application*: WB, E
Datasheet SDS

Mouse Anti-INPP4B Recombinant Antibody (CBYJT-1400) (CBMAB-T0422-YJ)

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Target: INPP4B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1400
Application*: WB, IP, E
Datasheet SDS

Rabbit Anti-INPP4B Recombinant Antibody (CBYY-I1697) (CBMAB-I2867-YY)

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Target: INPP4B
Host: Rabbit
Specificity: Human
Clone: CBYY-I1697
Application*: WB, IP, P
Datasheet SDS

Rabbit Anti-INPP4B Recombinant Antibody (CBYY-I1648) (CBMAB-I2818-YY)

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Target: INPP4B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I1648
Application*: WB, IP
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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