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INPP4B

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]

Full Name

Inositol Polyphosphate-4-Phosphatase Type II B

Function

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580).
Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580).
The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).

Biological Process

Inositol phosphate dephosphorylationIEA:Ensembl
Inositol phosphate metabolic processTAS:Reactome
Phosphatidylinositol biosynthetic processTAS:Reactome
Phosphatidylinositol dephosphorylationIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm; Cytosol

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Anti-INPP4B antibodies

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Rabbit Anti-INPP4B Recombinant Antibody (D19B9) (CBMAB-CP1177-LY)

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Target: INPP4B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D19B9

Application*: WB, IP

Mouse Anti-INPP4B Recombinant Antibody (3F2) (CBMAB-A4487-LY)

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Target: INPP4B

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F2

Application*: WB, E

Mouse Anti-INPP4B Recombinant Antibody (CBYJT-1400) (CBMAB-T0422-YJ)

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Target: INPP4B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1400

Application*: WB, IP, E

Rabbit Anti-INPP4B Recombinant Antibody (CBYY-I1697) (CBMAB-I2867-YY)

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Target: INPP4B

Host: Rabbit

Specificity: Human

Clone: CBYY-I1697

Application*: WB, IP, P

Rabbit Anti-INPP4B Recombinant Antibody (CBYY-I1648) (CBMAB-I2818-YY)

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Target: INPP4B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-I1648

Application*: WB, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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