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Mouse Anti-INS1 Recombinant Antibody (CBFYC-2785) (CBMAB-C2861-FY)

This product is mouse antibody that recognizes INS1. The antibody CBFYC-2785 can be used for immunoassay techniques such as: ELISA.
See all INS1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYC-2785
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Fragments of rat C-peptide conjugated to a carrier protein
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
insulin 1
Introduction
Ins1 is a 'defective gene' relative to Ins2, and that the mouse lines created provide a novel model of sex-dimorphic insulin-deficient diabetes.
Entrez Gene ID
24505
UniProt ID
P01322
Alternative Names
C-Peptide I
Function
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Biological Process
Glucose homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Glucose metabolic processIEA:UniProtKB-KW
Positive regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Response to cAMPManual Assertion Based On ExperimentIEP:RGD
Response to cytokineManual Assertion Based On ExperimentIEP:RGD
Response to organic substanceManual Assertion Based On ExperimentIEP:RGD
Response to peptide hormoneManual Assertion Based On ExperimentIEP:RGD

James, D. E., Stöckli, J., & Birnbaum, M. J. (2021). The aetiology and molecular landscape of insulin resistance. Nature Reviews Molecular Cell Biology, 22(11), 751-771.

Campbell, J. E., & Newgard, C. B. (2021). Mechanisms controlling pancreatic islet cell function in insulin secretion. Nature reviews Molecular cell biology, 22(2), 142-158.

Kojta, I., Chacińska, M., & Błachnio-Zabielska, A. (2020). Obesity, bioactive lipids, and adipose tissue inflammation in insulin resistance. Nutrients, 12(5), 1305.

Tagi, V. M., Giannini, C., & Chiarelli, F. (2019). Insulin resistance in children. Frontiers in endocrinology, 10, 342.

Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. (2019). Insulin resistance: Review of the underlying molecular mechanisms. Journal of cellular physiology, 234(6), 8152-8161.

Sokolowska, E., & Blachnio-Zabielska, A. (2019). The role of ceramides in insulin resistance. Frontiers in Endocrinology, 10, 577.

Heianza, Y., Sun, D., Li, X., DiDonato, J. A., Bray, G. A., Sacks, F. M., & Qi, L. (2019). Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial. Gut, 68(2), 263-270.

Rosenstock, J., Cheng, A., Ritzel, R., Bosnyak, Z., Devisme, C., Cali, A. M., ... & Bolli, G. B. (2018). More similarities than differences testing insulin glargine 300 units/mL versus insulin degludec 100 units/mL in insulin-naive type 2 diabetes: the randomized head-to-head BRIGHT trial. Diabetes care, 41(10), 2147-2154.

Ruegsegger, G. N., Creo, A. L., Cortes, T. M., Dasari, S., & Nair, K. S. (2018). Altered mitochondrial function in insulin-deficient and insulin-resistant states. The Journal of clinical investigation, 128(9), 3671-3681.

Petersen, M. C., & Shulman, G. I. (2018). Mechanisms of insulin action and insulin resistance. Physiological reviews.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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