Mouse Anti-INS1 Recombinant Antibody (CBFYC-2785) (CBMAB-C2861-FY)

Name: Mouse Anti-INS1 Recombinant Antibody (CBFYC-2785)
SKU: CBMAB-C2861-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2785

Application

ELISA

Immunogen

Fragments of rat C-peptide conjugated to a carrier protein

Specificity

Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

insulin 1

Introduction

Ins1 is a 'defective gene' relative to Ins2, and that the mouse lines created provide a novel model of sex-dimorphic insulin-deficient diabetes.

Entrez Gene ID

24505

UniProt ID

P01322

Alternative Names

C-Peptide I

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Biological Process

Glucose homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Glucose metabolic processIEA:UniProtKB-KW
Positive regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Response to cAMPManual Assertion Based On ExperimentIEP:RGD
Response to cytokineManual Assertion Based On ExperimentIEP:RGD
Response to organic substanceManual Assertion Based On ExperimentIEP:RGD
Response to peptide hormoneManual Assertion Based On ExperimentIEP:RGD

James, D. E., Stöckli, J., & Birnbaum, M. J. (2021). The aetiology and molecular landscape of insulin resistance. Nature Reviews Molecular Cell Biology, 22(11), 751-771.

Campbell, J. E., & Newgard, C. B. (2021). Mechanisms controlling pancreatic islet cell function in insulin secretion. Nature reviews Molecular cell biology, 22(2), 142-158.

Kojta, I., Chacińska, M., & Błachnio-Zabielska, A. (2020). Obesity, bioactive lipids, and adipose tissue inflammation in insulin resistance. Nutrients, 12(5), 1305.

Tagi, V. M., Giannini, C., & Chiarelli, F. (2019). Insulin resistance in children. Frontiers in endocrinology, 10, 342.

Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. (2019). Insulin resistance: Review of the underlying molecular mechanisms. Journal of cellular physiology, 234(6), 8152-8161.

Sokolowska, E., & Blachnio-Zabielska, A. (2019). The role of ceramides in insulin resistance. Frontiers in Endocrinology, 10, 577.

Heianza, Y., Sun, D., Li, X., DiDonato, J. A., Bray, G. A., Sacks, F. M., & Qi, L. (2019). Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial. Gut, 68(2), 263-270.

Rosenstock, J., Cheng, A., Ritzel, R., Bosnyak, Z., Devisme, C., Cali, A. M., ... & Bolli, G. B. (2018). More similarities than differences testing insulin glargine 300 units/mL versus insulin degludec 100 units/mL in insulin-naive type 2 diabetes: the randomized head-to-head BRIGHT trial. Diabetes care, 41(10), 2147-2154.

Ruegsegger, G. N., Creo, A. L., Cortes, T. M., Dasari, S., & Nair, K. S. (2018). Altered mitochondrial function in insulin-deficient and insulin-resistant states. The Journal of clinical investigation, 128(9), 3671-3681.

Petersen, M. C., & Shulman, G. I. (2018). Mechanisms of insulin action and insulin resistance. Physiological reviews.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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