Mouse Anti-INSL3 Recombinant Antibody (CBCNI-025) (CBMAB-R0552-CN)

Name: Mouse Anti-INSL3 Recombinant Antibody (CBCNI-025)
SKU: CBMAB-R0552-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNI-025

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Insulin Like Protein 3

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

Insulin Like 3

Introduction

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Entrez Gene ID

3640

UniProt ID

P51460

Alternative Names

Insulin Like 3

Function

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Oocyte maturationIEA:Ensembl
Positive regulation of cAMP-mediated signalingIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of wound healingManual Assertion Based On ExperimentIDA:CACAO
SpermatogenesisManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

Involvement in disease

Cryptorchidism (CRYPTO):
One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.

Ivell, R., Mamsen, L. S., Andersen, C. Y., & Anand-Ivell, R. (2022). Expression and role of INSL3 in the fetal testis. Frontiers in Endocrinology, 13, 868313.

Anand‐Ivell, R., Heng, K., Severn, K., Antonio, L., Bartfai, G., Casanueva, F. F., ... & Ivell, R. (2022). Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort. Andrology, 10(7), 1328-1338.

Yeom, E., Shin, H., Yoo, W., Jun, E., Kim, S., Hong, S. H., ... & Yu, K. (2021). Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. Nature Cell Biology, 23(2), 172-183.

Zhu, J., & Zheng, X. (2021). Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy. Journal of Clinical Laboratory Analysis, 35(9), e23898.

Ivell, R., Alhujaili, W., Kohsaka, T., & Anand-Ivell, R. (2020). Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates. General and Comparative Endocrinology, 299, 113583.

Suteau, V., Briet, C., Lebeault, M., Gourdin, L., Henrion, D., Rodien, P., & Munier, M. (2020). Human amniotic fluid-based exposure levels of phthalates and bisphenol A mixture reduce INSL3/RXFP2 signaling. Environment international, 138, 105585.

Sansone, A., Kliesch, S., Isidori, A. M., & Schlatt, S. A. M. H. (2019). AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know?. Andrology, 7(2), 131-138.

De Toni, L., Agoulnik, A. I., Sandri, M., Foresta, C., & Ferlin, A. (2019). INSL3 in the muscolo-skeletal system. Molecular and cellular endocrinology, 487, 12-17.

Sharma, V., Lehmann, T., Stuckas, H., Funke, L., & Hiller, M. (2018). Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals. PLoS biology, 16(6), e2005293.

Ferlin, A., De Toni, L., Agoulnik, A. I., Lunardon, G., Armani, A., Bortolanza, S., ... & Foresta, C. (2018). Protective role of testicular hormone INSL3 from atrophy and weakness in skeletal muscle. Frontiers in Endocrinology, 9, 562.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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