Sign in or Register   Sign in or Register
  |  

Mouse Anti-INSL3 Recombinant Antibody (CBCNI-025) (CBMAB-R0552-CN)

This product is a Mouse antibody that recognizes INSL3. The antibody CBCNI-025 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all INSL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNI-025
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Insulin Like Protein 3
Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
Insulin Like 3
Introduction
This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Entrez Gene ID
3640
UniProt ID
P51460
Alternative Names
Insulin Like 3
Function
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Oocyte maturationIEA:Ensembl
Positive regulation of cAMP-mediated signalingIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of wound healingManual Assertion Based On ExperimentIDA:CACAO
SpermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Involvement in disease
Cryptorchidism (CRYPTO):
One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.

Ivell, R., Mamsen, L. S., Andersen, C. Y., & Anand-Ivell, R. (2022). Expression and role of INSL3 in the fetal testis. Frontiers in Endocrinology, 13, 868313.

Anand‐Ivell, R., Heng, K., Severn, K., Antonio, L., Bartfai, G., Casanueva, F. F., ... & Ivell, R. (2022). Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort. Andrology, 10(7), 1328-1338.

Yeom, E., Shin, H., Yoo, W., Jun, E., Kim, S., Hong, S. H., ... & Yu, K. (2021). Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. Nature Cell Biology, 23(2), 172-183.

Zhu, J., & Zheng, X. (2021). Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy. Journal of Clinical Laboratory Analysis, 35(9), e23898.

Ivell, R., Alhujaili, W., Kohsaka, T., & Anand-Ivell, R. (2020). Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates. General and Comparative Endocrinology, 299, 113583.

Suteau, V., Briet, C., Lebeault, M., Gourdin, L., Henrion, D., Rodien, P., & Munier, M. (2020). Human amniotic fluid-based exposure levels of phthalates and bisphenol A mixture reduce INSL3/RXFP2 signaling. Environment international, 138, 105585.

Sansone, A., Kliesch, S., Isidori, A. M., & Schlatt, S. A. M. H. (2019). AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know?. Andrology, 7(2), 131-138.

De Toni, L., Agoulnik, A. I., Sandri, M., Foresta, C., & Ferlin, A. (2019). INSL3 in the muscolo-skeletal system. Molecular and cellular endocrinology, 487, 12-17.

Sharma, V., Lehmann, T., Stuckas, H., Funke, L., & Hiller, M. (2018). Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals. PLoS biology, 16(6), e2005293.

Ferlin, A., De Toni, L., Agoulnik, A. I., Lunardon, G., Armani, A., Bortolanza, S., ... & Foresta, C. (2018). Protective role of testicular hormone INSL3 from atrophy and weakness in skeletal muscle. Frontiers in Endocrinology, 9, 562.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-INSL3 Recombinant Antibody (CBCNI-025)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare