Rat Insl3 ELISA Kit (V2LY-0626-LY2388)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.032 ng/mL
Detection Range
0.06-18 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
14.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Insulin Like 3
Function
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Oocyte maturationIEA:Ensembl
Positive regulation of cAMP-mediated signalingIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of wound healingManual Assertion Based On ExperimentIDA:CACAO
SpermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Involvement in disease
Cryptorchidism (CRYPTO):
One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.

Ivell, R., Mamsen, L. S., Andersen, C. Y., & Anand-Ivell, R. (2022). Expression and role of INSL3 in the fetal testis. Frontiers in Endocrinology, 13, 868313.

Anand‐Ivell, R., Heng, K., Severn, K., Antonio, L., Bartfai, G., Casanueva, F. F., ... & Ivell, R. (2022). Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort. Andrology, 10(7), 1328-1338.

Yeom, E., Shin, H., Yoo, W., Jun, E., Kim, S., Hong, S. H., ... & Yu, K. (2021). Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. Nature Cell Biology, 23(2), 172-183.

Zhu, J., & Zheng, X. (2021). Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy. Journal of Clinical Laboratory Analysis, 35(9), e23898.

Ivell, R., Alhujaili, W., Kohsaka, T., & Anand-Ivell, R. (2020). Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates. General and Comparative Endocrinology, 299, 113583.

Suteau, V., Briet, C., Lebeault, M., Gourdin, L., Henrion, D., Rodien, P., & Munier, M. (2020). Human amniotic fluid-based exposure levels of phthalates and bisphenol A mixture reduce INSL3/RXFP2 signaling. Environment international, 138, 105585.

Sansone, A., Kliesch, S., Isidori, A. M., & Schlatt, S. A. M. H. (2019). AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know?. Andrology, 7(2), 131-138.

De Toni, L., Agoulnik, A. I., Sandri, M., Foresta, C., & Ferlin, A. (2019). INSL3 in the muscolo-skeletal system. Molecular and cellular endocrinology, 487, 12-17.

Sharma, V., Lehmann, T., Stuckas, H., Funke, L., & Hiller, M. (2018). Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals. PLoS biology, 16(6), e2005293.

Ferlin, A., De Toni, L., Agoulnik, A. I., Lunardon, G., Armani, A., Bortolanza, S., ... & Foresta, C. (2018). Protective role of testicular hormone INSL3 from atrophy and weakness in skeletal muscle. Frontiers in Endocrinology, 9, 562.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human INSL3 ELISA Kit (CAT#: V2LY-0626-LY3602)

Dog INSL3 ELISA Kit (CAT#: V2LY-0626-LY761)

Related Products

Dog INSL3 ELISA Kit (CAT#: V2LY-0626-LY761)

Human INSL3 ELISA Kit (CAT#: V2LY-0626-LY3602)

Mouse Anti-INSL3 Recombinant Antibody (CBCNI-025) (CAT#: CBMAB-R0552-CN)

Isotype control

For research use only. Not intended for any clinical use.

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