Mouse Anti-INSM1 Recombinant Antibody (CBYY-I1490) (CBMAB-I2660-YY)

Name: Mouse Anti-INSM1 Recombinant Antibody (CBYY-I1490)
SKU: CBMAB-I2660-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1490

Application

WB, IP, IF, IHC-P, ELISA

Specificity

Human, Mouse, Rat

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

INSM1

Introduction

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.

Entrez Gene ID

Human	3642
Mouse	53626
Rat	100912563

UniProt ID

Human	Q01101
Mouse	Q63ZV0
Rat	A0A1S3G366

Alternative Names

INSM Transcriptional Repressor 1

Function

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412).
Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation

Biological Process

Adrenal chromaffin cell differentiationISS:UniProtKB
Cell cycleIEA:UniProtKB-KW
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Noradrenergic neuron developmentISS:UniProtKB
Norepinephrine biosynthetic processISS:UniProtKB
Pancreatic A cell differentiationISS:UniProtKB
Positive regulation of cell differentiationISS:UniProtKB
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of neural precursor cell proliferationISS:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycle processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionISS:UniProtKB
Regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Ssympathetic ganglion developmentISS:UniProtKB
TransdifferentiationManual Assertion Based On ExperimentIDA:UniProtKB
Type B pancreatic cell developmentIEA:Ensembl
Type B pancreatic cell differentiationISS:UniProtKB

Cellular Location

Nucleus

Chen, C., & Lan, M. S. (2022). Interplay: The Essential Role between INSM1 and N-Myc in Aggressive Neuroblastoma. Biology, 11(10), 1376.

Razvi, H., Tsang, J. Y., Poon, I. K., Chan, S. K., Cheung, S. Y., Shea, K. H., & Gary, M. T. (2021). INSM1 is a novel prognostic neuroendocrine marker for luminal B breast cancer. Pathology, 53(2), 170-178.

Maleki, Z., Nadella, A., Nadella, M., Patel, G., Patel, S., & Kholová, I. (2021). INSM1, a novel biomarker for detection of neuroendocrine neoplasms: cytopathologists’ view. Diagnostics, 11(12), 2172.

Metovic, J., Castellano, I., Marinelli, E., Osella-Abate, S., Sapino, A., Cassoni, P., & Papotti, M. (2021). INSM1 expression in breast neoplasms with neuroedocrine features. Endocrine Pathology, 32, 452-460.

Zou, Q., Zhang, L., Cheng, Z., Guo, X., & Cao, D. (2021). INSM1 is less sensitive but more specific than synaptophysin in gynecologic high-grade neuroendocrine carcinomas: an immunohistochemical study of 75 cases with specificity test and literature review. The American Journal of Surgical Pathology, 45(2), 147-159.

Asrani, K., Torres, A. F., Woo, J., Vidotto, T., Tsai, H. K., Luo, J., ... & Lotan, T. L. (2021). Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer. The Journal of Pathology, 255(4), 425-437.

Lilo, M. T., Chen, Y., & LeBlanc, R. E. (2018). INSM1 is more sensitive and interpretable than conventional immunohistochemical stains used to diagnose Merkel cell carcinoma. The American journal of surgical pathology, 42(11), 1541-1548.

Wiwatpanit, T., Lorenzen, S. M., Cantú, J. A., Foo, C. Z., Hogan, A. K., Márquez, F., ... & García-Añoveros, J. (2018). Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1. Nature, 563(7733), 691-695.

Rooper, L. M., Bishop, J. A., & Westra, W. H. (2018). INSM1 is a sensitive and specific marker of neuroendocrine differentiation in head and neck tumors. The American journal of surgical pathology, 42(5), 665-671.

Yoshida, A., Makise, N., Wakai, S., Kawai, A., & Hiraoka, N. (2018). INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. Modern Pathology, 31(5), 744-752.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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