INSM1

INSM1 (insulinoma-associated 1) is a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. INSM1 is a sensitive marker for neuroendocrine differentiation of human lung tumors.

Full Name

INSM1

Function

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412).
Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation

Biological Process

Adrenal chromaffin cell differentiationISS:UniProtKB
Cell cycleIEA:UniProtKB-KW
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Noradrenergic neuron developmentISS:UniProtKB
Norepinephrine biosynthetic processISS:UniProtKB
Pancreatic A cell differentiationISS:UniProtKB
Positive regulation of cell differentiationISS:UniProtKB
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of neural precursor cell proliferationISS:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycle processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionISS:UniProtKB
Regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Ssympathetic ganglion developmentISS:UniProtKB
TransdifferentiationManual Assertion Based On ExperimentIDA:UniProtKB
Type B pancreatic cell developmentIEA:Ensembl
Type B pancreatic cell differentiationISS:UniProtKB

Cellular Location

Nucleus