Rabbit Anti-ITPKA Recombinant Antibody (EG1656) (CBMAB-EN1984-LY)

The product is antibody recognizes IP3KA. The antibody EG1656 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all ITPKA antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1656

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from C-terminal of human IP3KA.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

inositol-trisphosphate 3-kinase A

Introduction

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

Entrez Gene ID

Human	3706
Mouse	228550
Rat	81677

UniProt ID

Human	P23677
Mouse	Q8R071
Rat	P17105

Alternative Names

IP3KA; IP3-3KA

Biological Process

Actin cytoskeleton organizationIEA:Ensembl
Dendritic spine maintenanceIEA:Ensembl
Inositol metabolic processIEA:Ensembl
Inositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of dendritic spine morphogenesisIEA:Ensembl
Regulation of synaptic plasticityIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm; Cytosol; Dendritic spine; Nucleus

References

Küster, L., Paraschiakos, T., Karakurt, K. E., Schumacher, U., Diercks, B. P., & Windhorst, S. (2023). The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells. Bioscience Reports, 43(2), BSR20222150.

Zhang, X., He, J., & Ren, D. (2023). Commentary on: The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells. Bioscience Reports, 43(9), BSR20230057.

Liu, J., Zhang, C., Wang, J., Huang, Y., Shen, D., Hu, Y., ... & Ma, H. (2022). A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca2+ Signaling Pathway. Pharmaceuticals, 15(12), 1481.

Zhang, J., Zhang, S., Li, X., & Pi, H. (2021). Relationship of ITPKA expression with the prognosis of breast cancer. Molecular genetics & genomic medicine, 9(4), e1598.

Shaosheng, W., Shaochuang, W., Lichun, F., Na, X., & Xiaohong, Z. (2021). ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203. Aging (albany NY), 13(8), 11822.

Guoren, Z., Zhaohui, F., Wei, Z., Mei, W., Yuan, W., Lin, S., ... & Bo, S. (2020). TFAP2A induced ITPKA serves as an oncogene and interacts with DBN1 in lung adenocarcinoma. International Journal of Biological Sciences, 16(3), 504.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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