ITPKA

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

Full Name

inositol-trisphosphate 3-kinase A

Biological Process

Actin cytoskeleton organizationIEA:Ensembl
Dendritic spine maintenanceIEA:Ensembl
Inositol metabolic processIEA:Ensembl
Inositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of dendritic spine morphogenesisIEA:Ensembl
Regulation of synaptic plasticityIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm; Cytosol; Dendritic spine; Nucleus