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Rabbit Anti-IRX3 Recombinant Antibody (BA0099) (CBMAB-0394CQ)

This product is a rabbit antibody that recognizes IRX3. The antibody BA0099 can be used for immunoassay techniques such as: FC, WB.
See all IRX3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0099
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Human Iroquois homeobox protein 3 aa 50-150 (Cysteine residue)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
iroquois homeobox 3
Introduction
IRX3 is a member of the Iroquois homeobox gene family and plays a role in an early step of neural development. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos. Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
Entrez Gene ID
Human79191
Mouse16373
Rat307721
UniProt ID
HumanP78415
MouseP81067
RatD3ZNE0
Alternative Names
IRX-1; IRXB1
Function
Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
Biological Process
Atrioventricular bundle cell differentiationISS:BHF-UCL
Cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Energy homeostasisISS:UniProtKB
His-Purkinje system cell differentiationISS:BHF-UCL
Mesoderm developmentIEA:Ensembl
Metanephros developmentIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gap junction assemblyBy SimilarityISS:BHF-UCL
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Purkinje myocyte developmentISS:BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conductionBy SimilarityISS:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Specification of loop of Henle identityIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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