IRX3

IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.

Full Name

iroquois homeobox 3

Function

Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.

Biological Process

Atrioventricular bundle cell differentiationISS:BHF-UCL
Cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Energy homeostasisISS:UniProtKB
His-Purkinje system cell differentiationISS:BHF-UCL
Mesoderm developmentIEA:Ensembl
Metanephros developmentIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gap junction assemblyBy SimilarityISS:BHF-UCL
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Purkinje myocyte developmentISS:BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conductionBy SimilarityISS:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Specification of loop of Henle identityIEA:Ensembl

Cellular Location

Nucleus