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Mouse Anti-ITGA9 Recombinant Antibody (3E4) (CBMAB-A4579-LY)

The product is antibody recognizes ITGA9. The antibody 3E4 immunoassay techniques such as: WB, ELISA.
See all ITGA9 antibodies
Published Data
Fig. 1 Panel of western blots showing the effects of GSI on full-length N-cadherin (N-Cad/FL) and CTF2 fragment, a9-integrin (ITGA9), NICD and Hes1 levels compared with untreated samples (DMSO).
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Fig. 2 α9-integrin immunocytochemistry
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Fig. 3 The expression of α9-integrin correlate in archival RMS tumour samples.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3E4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
ITGA9 (NP_002198, 785 a.a. ~ 886 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
integrin, alpha 9
Introduction
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq]
Entrez Gene ID
3680
UniProt ID
Q13797
Alternative Names
ALPHA-RLC; ITGA4L; RLC
Function
Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Biological Process
Cell adhesionManual Assertion Based On ExperimentIGI:MGI
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Neutrophil chemotaxisIEA:Ensembl
Topology
Extracellular: 30-981
Helical: 982-1002
Cytoplasmic: 1003-1035

Jin, S., Song, Y., Zhou, L., Jiang, W., Qin, L., Wang, Y., ... & Sun, G. (2023). Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. Cell Reports, 42(6).

Wu, Y., Chen, J., Tan, F., Wang, B., Xu, W., & Yuan, C. (2022). ITGA9: potential biomarkers and therapeutic targets in different tumors. Current Pharmaceutical Design, 28(17), 1412-1418.

Ciechanowska, A., Rojewska, E., Piotrowska, A., Barut, J., Pawlik, K., Ciapała, K., ... & Mika, J. (2022). New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions-evidence from animal studies. Frontiers in Immunology, 13, 1058204.

Hou, H., Li, J., Wang, J., Zhou, L., Li, J., Liang, J., ... & Zhang, K. (2022). ITGA9 Inhibits Proliferation and Migration of Dermal Microvascular Endothelial Cells in Psoriasis. Clinical, Cosmetic and Investigational Dermatology, 2795-2806.

Xu, Y., Zhang, J., Zhang, Q., Xu, H., & Liu, L. (2021). Long non-coding RNA HOXA11-AS modulates proliferation, apoptosis, metastasis and EMT in cutaneous melanoma cells partly via miR-152-3p/ITGA9 axis. Cancer management and research, 925-939.

Fan, J., Kang, X., Zhao, L., Zheng, Y., Yang, J., & Li, D. (2020). RETRACTED ARTICLE: Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma. Cancer Management and Research, 4699-4714.

Xu, T. J., Qiu, P., Zhang, Y. B., Yu, S. Y., Xu, G. M., & Yang, W. (2019). MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9. Human cell, 32(4), 548-556.

Liu, J., Liu, T., Liang, L., He, J., Zhang, M., Ge, Y., ... & Zhang, K. (2019). Clinical relationships between the rs2212020 and rs189897 polymorphisms of the ITGA9 gene and epithelial ovarian cancer. Journal of genetics, 98, 1-8.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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