ITGA9

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq]

integrin, alpha 9

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

Cell adhesionManual Assertion Based On ExperimentIGI:MGI
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Neutrophil chemotaxisIEA:Ensembl

Extracellular: 30-981
Helical: 982-1002
Cytoplasmic: 1003-1035