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Mouse Anti-ITIH5 Recombinant Antibody (CBYY-I1567) (CBMAB-I2737-YY)

This product is Mouse antibody that recognizes ITIH5. The antibody CBYY-I1567 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all ITIH5 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBYY-I1567
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
inter-alpha (globulin) inhibitor H5
Introduction
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
209378
UniProt ID
Q8BJD1
Alternative Names
Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 5
Function
May act as a tumor suppressor.
Biological Process
Hyaluronan metabolic processIEA:InterPro
Cellular Location
Secreted

Rose, M., Huth, S., Wiesehöfer, M., Ehling, J., Henkel, C., Steitz, J., ... & Dahl, E. (2022). ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro. Cancers, 14(3), 488.

Zou, L., He, H., Li, Z., Chen, O., Jia, X., & Zhang, H. (2021). Long noncoding RNA LINC00261 upregulates ITIH5 to impair tumorigenic ability of pancreatic cancer stem cells. Cell Death Discovery, 7(1), 220.

Young, E. D., Manley, S. J., Beadnell, T. C., Shearin, A. E., Sasaki, K., Zimmerman, R., ... & Welch, D. R. (2021). Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5. British journal of cancer, 124(1), 166-175.

Liu, J., Cao, F., Li, X., Zhang, L., Liu, Z., Li, X., ... & Han, C. (2021). ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4. Cell Death & Disease, 12(5), 438.

Daum, A. K., Dittmann, J., Jansen, L., Peters, S., Dahmen, U., Heger, J. I., ... & Backsch, C. (2021). ITIH5 shows tumor suppressive properties in cervical cancer cells grown as multicellular tumor spheroids. American journal of translational research, 13(9), 10298.

Rose, M., Noetzel, E., Kistermann, J., Eschenbruch, J., Rushrush, S., Gan, L., ... & Dahl, E. (2021). The ECM modulator ITIH5 affects cell adhesion, motility and chemotherapeutic response of basal/squamous-like (BASQ) bladder cancer cells. Cells, 10(5), 1038.

Huth, S., Huth, L., Marquardt, Y., Fietkau, K., Dahl, E., Esser, P. R., ... & Baron, J. M. (2020). Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is a natural stabilizer of hyaluronan that modulates biological processes in the skin. Skin Pharmacology and Physiology, 33(4), 198-206.

Rose, M., Bringezu, S., Godfrey, L., Fiedler, D., Gaisa, N. T., Koch, M., ... & Dahl, E. (2020). ITIH5 and ECRG4 DNA methylation biomarker test (EI-BLA) for urine-based non-invasive detection of bladder cancer. International Journal of Molecular Sciences, 21(3), 1117.

Rose, M., Meurer, S. K., Kloten, V., Weiskirchen, R., Denecke, B., Antonopoulos, W., ... & Dahl, E. (2018). ITIH5 induces a shift in TGF‐β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death. Molecular carcinogenesis, 57(2), 167-181.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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