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Mouse Anti-ITM2C Recombinant Antibody (A703) (CBMAB-AP10928LY)

The product is antibody recognizes ITM2C. The antibody A703 immunoassay techniques such as: ELISA, IF.
See all ITM2C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A703
Antibody Isotype
IgG2a
Application
ELISA, IF

Basic Information

Immunogen
Fusion protein of ITM2C
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Integral Membrane Protein 2C
Introduction
ITM2C (Integral Membrane Protein 2C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include amyloid-beta binding. An important paralog of this gene is ITM2B.
Entrez Gene ID
81618
UniProt ID
Q9NQX7
Alternative Names
Integral Membrane Protein 2C
Function
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
Biological Process
Negative regulation of amyloid precursor protein biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Cellular Location
Lysosome membrane; Cell membrane
Topology
Helical: 55-75
PTM
Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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