ITM2C

ITM2C (Integral Membrane Protein 2C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include amyloid-beta binding. An important paralog of this gene is ITM2B.

Full Name

Integral Membrane Protein 2C

Function

Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).

Biological Process

Negative regulation of amyloid precursor protein biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl

Cellular Location

Lysosome membrane; Cell membrane

Topology

Helical: 55-75

PTM

Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B.