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Mouse Anti-JAG1 Recombinant Antibody (3C10) (CBMAB-0176-WJ)

This product is a mouse antibody that recognizes JAG1. The antibody 3C10 can be used for immunoassay techniques such as: ELISA, WB.
See all JAG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C10
Antibody Isotype
IgG2b, Κ
Application
ELISA, WB

Basic Information

Immunogen
JAG1 (amino acid 905-1014) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
JAG1
Introduction
JAG1 (Jagged 1) is a Protein Coding gene. The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Diseases associated with JAG1 include Alagille Syndrome 1 and Tetralogy Of Fallot. Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis.
Entrez Gene ID
UniProt ID
Alternative Names
AGS; AHD; AWS; HJ1; AGS1; CD339; JAGL1
Function
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614).
May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510).
Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity).
Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Biological Process
Angiogenesis1 PublicationNAS:UniProtKB
Aorta morphogenesisISS:BHF-UCL
Aortic valve morphogenesis1 PublicationNAS:BHF-UCL
Blood vessel remodelingIEA:Ensembl
Cardiac neural crest cell development involved in outflow tract morphogenesisISS:BHF-UCL
Cardiac right ventricle morphogenesisISS:BHF-UCL
Cardiac septum morphogenesisISS:BHF-UCL
Cell fate determination1 PublicationNAS:UniProtKB
Ciliary body morphogenesisIEA:Ensembl
Distal tubule developmentIEA:Ensembl
Endocardial cushion cell developmentISS:BHF-UCL
Endothelial cell differentiation1 PublicationNAS:UniProtKB
Glomerular visceral epithelial cell developmentISS:UniProtKB
Hemopoiesis1 PublicationNAS:UniProtKB
Inner ear auditory receptor cell differentiationIEA:Ensembl
Keratinocyte differentiation1 PublicationNAS:UniProtKB
Loop of Henle developmentIEA:Ensembl
Morphogenesis of an epithelial sheetIEA:Ensembl
Myoblast differentiation1 PublicationNAS:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell-matrix adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of endothelial cell differentiationIEA:Ensembl
Negative regulation of fat cell differentiationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of stem cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Nephron developmentISS:UniProtKB
Nervous system development1 PublicationNAS:UniProtKB
Neuronal stem cell population maintenanceManual Assertion Based On ExperimentIEP:UniProtKB
Notch signaling involved in heart developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Notch signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cardiac epithelial to mesenchymal transitionISS:BHF-UCL
Positive regulation of myeloid cell differentiationIEA:Ensembl
Positive regulation of Notch signaling pathwayISS:UniProtKB
Positive regulation of osteoblast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Pulmonary artery morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Pulmonary valve morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cell population proliferation1 PublicationNAS:UniProtKB
Response to muramyl dipeptideIEA:Ensembl
T cell mediated immunityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Involvement in disease
Alagille syndrome 1 (ALGS1):
A form of Alagille syndrome, an autosomal dominant multisystem disorder. It is clinically defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
Tetralogy of Fallot (TOF):
A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
Deafness, congenital heart defects, and posterior embryotoxon (DCHE):
An autosomal dominant disease characterized by mild to severe combined hearing loss, congenital heart defects, and posterior embryotoxon, a corneal abnormality consisting of a central collagen core surrounded by a thin layer of Descemets membrane and separated from the anterior chamber by a layer of endothelium. Congenital heart defects include tetralogy of Fallot, ventricular septal defect, or isolated peripheral pulmonic stenosis.
Topology
Extracellular: 34-1067
Helical: 1068-1093
Cytoplasmic: 1094-1218
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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