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JAG1

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq]
Full Name
JAG1
Function
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614).
May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510).
Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity).
Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Biological Process
Angiogenesis1 PublicationNAS:UniProtKB
Aorta morphogenesisISS:BHF-UCL
Aortic valve morphogenesis1 PublicationNAS:BHF-UCL
Blood vessel remodelingIEA:Ensembl
Cardiac neural crest cell development involved in outflow tract morphogenesisISS:BHF-UCL
Cardiac right ventricle morphogenesisISS:BHF-UCL
Cardiac septum morphogenesisISS:BHF-UCL
Cell fate determination1 PublicationNAS:UniProtKB
Ciliary body morphogenesisIEA:Ensembl
Distal tubule developmentIEA:Ensembl
Endocardial cushion cell developmentISS:BHF-UCL
Endothelial cell differentiation1 PublicationNAS:UniProtKB
Glomerular visceral epithelial cell developmentISS:UniProtKB
Hemopoiesis1 PublicationNAS:UniProtKB
Inner ear auditory receptor cell differentiationIEA:Ensembl
Keratinocyte differentiation1 PublicationNAS:UniProtKB
Loop of Henle developmentIEA:Ensembl
Morphogenesis of an epithelial sheetIEA:Ensembl
Myoblast differentiation1 PublicationNAS:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell-matrix adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of endothelial cell differentiationIEA:Ensembl
Negative regulation of fat cell differentiationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of stem cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Nephron developmentISS:UniProtKB
Nervous system development1 PublicationNAS:UniProtKB
Neuronal stem cell population maintenanceManual Assertion Based On ExperimentIEP:UniProtKB
Notch signaling involved in heart developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Notch signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cardiac epithelial to mesenchymal transitionISS:BHF-UCL
Positive regulation of myeloid cell differentiationIEA:Ensembl
Positive regulation of Notch signaling pathwayISS:UniProtKB
Positive regulation of osteoblast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Pulmonary artery morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Pulmonary valve morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cell population proliferation1 PublicationNAS:UniProtKB
Response to muramyl dipeptideIEA:Ensembl
T cell mediated immunityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Involvement in disease
Alagille syndrome 1 (ALGS1):
A form of Alagille syndrome, an autosomal dominant multisystem disorder. It is clinically defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
Tetralogy of Fallot (TOF):
A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
Deafness, congenital heart defects, and posterior embryotoxon (DCHE):
An autosomal dominant disease characterized by mild to severe combined hearing loss, congenital heart defects, and posterior embryotoxon, a corneal abnormality consisting of a central collagen core surrounded by a thin layer of Descemets membrane and separated from the anterior chamber by a layer of endothelium. Congenital heart defects include tetralogy of Fallot, ventricular septal defect, or isolated peripheral pulmonic stenosis.
Topology
Extracellular: 34-1067
Helical: 1068-1093
Cytoplasmic: 1094-1218

Anti-JAG1 antibodies

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Target: JAG1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJJ-005
Application*: IH
Target: JAG1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 12G31
Application*: F, IH
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L653
Application*: F, N, WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3A10
Application*: WB, IH
Target: JAG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: J1G74-7
Application*: E, F, WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0424-4A24
Application*: F, N
Target: JAG1
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-3932
Application*: F
Target: JAG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: S.522.2
Application*: WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TS106
Application*: F
Target: JAG1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJJ-002
Application*: E, WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: CBFYC-2850
Application*: WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MHJ1-152
Application*: F
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJJ-023
Application*: F
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 11D68
Application*: F
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1B7
Application*: E, WB
Target: JAG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1C4
Application*: WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E12
Application*: E, WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 241002
Application*: F
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3
Application*: F
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3C10
Application*: E, WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 4A24
Application*: F, N
Target: JAG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 7H29
Application*: E, WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9G373
Application*: E, WB
Target: JAG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: J.841.5
Application*: IP, WB
Target: JAG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: J1G53-3
Application*: E, WB, IH, F
Target: JAG1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: OTI3A10
Application*: WB, IH
Target: JAG1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJJ-004
Application*: F, IH
Target: JAG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1C4
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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