Hamster Anti-JAG2 Recombinant Antibody (CBWJJ-013) (CBMAB-0471-WJ)

Name: Hamster Anti-JAG2 Recombinant Antibody (CBWJJ-013)
SKU: CBMAB-0471-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Hamster

Clone

CBWJJ-013

Application

IHC

Specificity

Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

JAG2

Introduction

JAG2 (Jagged 2) is a Protein Coding gene. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Diseases associated with JAG2 include Ossifying Fibroma and Shipyard Eye. An important paralog of this gene is JAG1.

Entrez Gene ID

16450

UniProt ID

Q9QYE5

Alternative Names

sm; Serh; D12Ggc2e; mJagged2-1

Function

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

Biological Process

Auditory receptor cell fate commitmentBy SimilarityISS:UniProtKB
Cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Epithelial cell apoptotic process involved in palatal shelf morphogenesisIEA:Ensembl
Gamma-delta T cell differentiationIEA:Ensembl
In utero embryonic developmentIEA:Ensembl
Morphogenesis of embryonic epitheliumIEA:Ensembl
Notch signaling pathway1 PublicationNAS:UniProtKB
Odontogenesis of dentin-containing toothIEA:Ensembl
Positive regulation of Notch signaling pathwayISS:UniProtKB
Regulation of cell adhesionIEA:Ensembl
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory system processIEA:Ensembl
Skeletal system developmentIEA:Ensembl
SpermatogenesisManual Assertion Based On ExperimentIEP:UniProtKB
T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Thymic T cell selectionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 27-1080
Helical: 1081-1101
Cytoplasmic: 1102-1238

Nakano, Y., Nakao, S., Sueoka, M., Kasahara, D., Tanno, Y., Sumiyoshi, H., ... & Inagaki, Y. (2022). Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice. Communications Biology, 5(1), 85.

Kamalakar, A., Oh, M. S., Stephenson, Y. C., Ballestas-Naissir, S. A., Davis, M. E., Willett, N. J., ... & Goudy, S. L. (2019). A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells. Cellular signalling, 54, 130-138.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

JAG2 Matched Antibody Pair (654) (CAT#: APMAB-654LY)

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Hamster Anti-JAG2 Recombinant Antibody (CBWJJ-012) (CAT#: CBMAB-0470-WJ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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