Mouse Anti-JAZF1 Antibody (1A5) (CBMAB-0564-YC)

Name: Mouse Anti-JAZF1 Antibody (1A5)
SKU: CBMAB-0564-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A5

Application

IP, WB, MA

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

JAZF1

Introduction

JAZF1 (JAZF zinc finger 1) is a nuclear protein with three C2H2-type zinc fingers. JAZF1 acts as a transcriptional repressor and chromosomal aberrations involving JAZF1 gene are associated with endometrial stromal tumors.

Entrez Gene ID

221895

UniProt ID

Q86VZ6

Alternative Names

TIP27; ZNF802

Function

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918).
Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity).
Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity).
Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity).
Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity).

Biological Process

Lipid metabolic processIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1.

Liu, Y., Ma, L., Li, M., Tian, Z., Yang, M., Wu, X., ... & Chen, Z. (2023). Structures of human TR4LBD–JAZF1 and TR4DBD–DNA complexes reveal the molecular basis of transcriptional regulation. Nucleic Acids Research, 51(3), 1443-1457.

Chen, W., Zhong, Y., Yuan, Y., Zhu, M., Hu, W., Liu, N., & Xing, D. (2022). New insights into the suppression of inflammation and lipid accumulation by JAZF1. Genes & Diseases.

Lee, H. Y., Jang, H. R., Li, H., Samuel, V. T., Dudek, K. D., Osipovich, A. B., ... & Shulman, G. I. (2022). Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice. Proceedings of the National Academy of Sciences, 119(49), e2213628119.

Gu, Y., Zhou, C., Guo, X., Huang, C., Liu, P., Hu, G., ... & Liu, P. (2022). Preparation of a JAZF1 protein polyclonal antibody and its potential role in broiler ascites syndrome. International Journal of Biological Macromolecules, 206, 501-510.

Wang, J. G., Jian, W. J., Li, Y., & Zhang, J. (2021). Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis. The Kaohsiung Journal of Medical Sciences, 37(7), 572-582.

Gupta, S. K., Jea, J. D. Y., & Yen, L. (2021). RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells. PLoS Genetics, 17(12), e1009985.

Kobiita, A., Godbersen, S., Araldi, E., Ghoshdastider, U., Schmid, M. W., Spinas, G., ... & Stoffel, M. (2020). The diabetes gene JAZF1 is essential for the homeostatic control of ribosome biogenesis and function in metabolic stress. Cell reports, 32(1).

Liao, Z. Z., Wang, Y. D., Qi, X. Y., & Xiao, X. H. (2019). JAZF1, a relevant metabolic regulator in type 2 diabetes. Diabetes/metabolism research and reviews, 35(5), e3148.

Sung, Y., Park, S., Park, S. J., Jeong, J., Choi, M., Lee, J., ... & Kim, M. O. (2018). Jazf1 promotes prostate cancer progression by activating JNK/Slug. Oncotarget, 9(1), 755.

Wei, Q., Zhou, B., Yang, G., Hu, W., Zhang, L., Liu, R., ... & Li, L. (2018). JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c-dependent mechanism. Cell death & disease, 9(9), 859.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-JAZF1 Antibody (1B8) (CAT#: CBMAB-0565-YC)

Isotype control

For research use only. Not intended for any clinical use.

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