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Mouse Anti-JAZF1 Recombinant Antibody (C-11) (CBMAB-0298-WJ)

This product is a mouse antibody that recognizes JAZF1. The antibody C-11 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all JAZF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
C-11
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
JAZF1
Introduction
JAZF1 (JAZF zinc finger 1) is a nuclear protein with three C2H2-type zinc fingers. JAZF1 acts as a transcriptional repressor and chromosomal aberrations involving JAZF1 gene are associated with endometrial stromal tumors.
Entrez Gene ID
221895
UniProt ID
Q86VZ6
Alternative Names
TIP27; ZNF802
Function
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918).
Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity).
Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity).
Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity).
Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity).
Biological Process
Lipid metabolic processIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1.

Liu, Y., Ma, L., Li, M., Tian, Z., Yang, M., Wu, X., ... & Chen, Z. (2023). Structures of human TR4LBD–JAZF1 and TR4DBD–DNA complexes reveal the molecular basis of transcriptional regulation. Nucleic Acids Research, 51(3), 1443-1457.

Chen, W., Zhong, Y., Yuan, Y., Zhu, M., Hu, W., Liu, N., & Xing, D. (2022). New insights into the suppression of inflammation and lipid accumulation by JAZF1. Genes & Diseases.

Lee, H. Y., Jang, H. R., Li, H., Samuel, V. T., Dudek, K. D., Osipovich, A. B., ... & Shulman, G. I. (2022). Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice. Proceedings of the National Academy of Sciences, 119(49), e2213628119.

Gu, Y., Zhou, C., Guo, X., Huang, C., Liu, P., Hu, G., ... & Liu, P. (2022). Preparation of a JAZF1 protein polyclonal antibody and its potential role in broiler ascites syndrome. International Journal of Biological Macromolecules, 206, 501-510.

Wang, J. G., Jian, W. J., Li, Y., & Zhang, J. (2021). Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis. The Kaohsiung Journal of Medical Sciences, 37(7), 572-582.

Gupta, S. K., Jea, J. D. Y., & Yen, L. (2021). RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells. PLoS Genetics, 17(12), e1009985.

Kobiita, A., Godbersen, S., Araldi, E., Ghoshdastider, U., Schmid, M. W., Spinas, G., ... & Stoffel, M. (2020). The diabetes gene JAZF1 is essential for the homeostatic control of ribosome biogenesis and function in metabolic stress. Cell reports, 32(1).

Liao, Z. Z., Wang, Y. D., Qi, X. Y., & Xiao, X. H. (2019). JAZF1, a relevant metabolic regulator in type 2 diabetes. Diabetes/metabolism research and reviews, 35(5), e3148.

Sung, Y., Park, S., Park, S. J., Jeong, J., Choi, M., Lee, J., ... & Kim, M. O. (2018). Jazf1 promotes prostate cancer progression by activating JNK/Slug. Oncotarget, 9(1), 755.

Wei, Q., Zhou, B., Yang, G., Hu, W., Zhang, L., Liu, R., ... & Li, L. (2018). JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c-dependent mechanism. Cell death & disease, 9(9), 859.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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