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Mouse Anti-JMJD1C Recombinant Antibody (5F12) (CBMAB-0232-WJ)

This product is a mouse antibody that recognizes JMJD1C. The antibody 5F12 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all JMJD1C antibodies
Published Data
Fig.1 Immunoblot of JMJD1C protein levels in different leukemic cell NEs. TBP served as a loading control.
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Fig.2 Morphologic changes (left, colony in methylcellulose; right, Wright-Giemsa stain) in HOXA9/MEIS1 preleukemia cells 10 days after transduction with CRE.
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Fig.3 Co-IP of HA-HOXA9 and KDM3A family members in 293T cells transfected with indicated plasmids.
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Fig.4 Immunoblot of JMJD1C protein levels in different leukemic cell NEs.
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Fig.5 Immunoprecipitation of JMJD1C from different AML cells to confirm HEB and LYL1 association.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
5F12
Antibody Isotype
IgG2a, Κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
JMJD1C (amino acid 2-100) paratial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
jumonji domain containing 1C
Introduction
The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Diseases associated with JMJD1C include Central Nervous System Germinoma and Rett Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Transcriptional misregulation in cancer. An important paralog of this gene is KDM3B.
Entrez Gene ID
221037
UniProt ID
Q15652
Alternative Names
JMJD1C; jumonji domain containing 1C; thyroid hormone receptor interactor 8, TRIP8; probable JmjC domain-containing histone demethylation protein 2C; DKFZp761F0118; FLJ14374; KIAA1380; TRIP-8; TR-interacting protein 8; jumonji domain-containing protein 1C; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; thyroid receptor-interacting protein 8; TRIP8; RP11-10C13.2
Function
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).
Biological Process
Blood coagulationTAS:Reactome
Chromatin organizationIEA:UniProtKB-KW
Histone H3-K9 demethylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus

Zhong, C., Tao, B., Yang, F., Xia, K., Yang, X., Chen, L., ... & Peng, L. (2021). Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR‐302a. Clinical and Translational Medicine, 11(9), e424.

Wang, J., Liu, X., Wang, H., Qin, L., Feng, A., Qi, D., ... & Xu, X. (2022). JMJD1C Regulates Megakaryopoiesis in In Vitro Models through the Actin Network. Cells, 11(22), 3660.

Yin, Y., Yang, X., Wu, S., Ding, X., Zhu, H., Long, X., ... & Wang, X. (2022). Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis. Nature immunology, 23(9), 1342-1354.

Qu, F., Wang, L., Wang, C., Yu, L., Zhao, K., & Zhong, H. (2021). Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis. Cancer Cell International, 21(1), 1-12.

Yu, S., Li, Y., Zhao, H., Wang, Q., & Chen, P. (2020). The histone demethylase JMJD1C regulates CAMKK2-AMPK signaling to participate in cardiac hypertrophy. Frontiers in physiology, 11, 539.

Viscarra, J. A., Wang, Y., Nguyen, H. P., Choi, Y. G., & Sul, H. S. (2020). Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. Nature communications, 11(1), 796.

Xu, X., Wang, L., Hu, L., Dirks, W. G., Zhao, Y., Wei, Z., ... & Hu, Z. (2020). Small molecular modulators of JMJD1C preferentially inhibit growth of leukemia cells. International journal of cancer, 146(2), 400-412.

Lynch, J. R., Salik, B., Connerty, P., Vick, B., Leung, H., Pijning, A., ... & Wang, J. Y. (2019). JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis. Leukemia, 33(6), 1400-1410.

Izaguirre-Carbonell, J., Christiansen, L., Burns, R., Schmitz, J., Li, C., Mokry, R. L., ... & Zhu, N. (2019). Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia. Blood advances, 3(9), 1499-1511.

Chen, C., Aihemaiti, M., Zhang, X., Qu, H., Sun, Q. L., He, Q. S., & Yu, W. B. (2018). Downregulation of histone demethylase JMJD1C inhibits colorectal cancer metastasis through targeting ATF2. American journal of cancer research, 8(5), 852.

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For research use only. Not intended for any clinical use.

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