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JMJD1C

The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Diseases associated with JMJD1C include Central Nervous System Germinoma and Rett Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Transcriptional misregulation in cancer. An important paralog of this gene is KDM3B.

Full Name

jumonji domain containing 1C

Function

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

Biological Process

Blood coagulationTAS:Reactome
Chromatin organizationIEA:UniProtKB-KW
Histone H3-K9 demethylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Nucleus

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Anti-JMJD1C antibodies

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Mouse Anti-JMJD1C Recombinant Antibody (5F12) (CBMAB-0232-WJ)

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Target: JMJD1C

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5F12

Application*: E, IH, WB

Mouse Anti-JMJD1C Recombinant Antibody (3A8) (CBMAB-0166-WJ)

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Target: JMJD1C

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3A8

Application*: E, WB

Mouse Anti-JMJD1C Recombinant Antibody (CBLXJ-040) (CBMAB-2198CQ)

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Target: JMJD1C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBLXJ-040

Application*: WB, IH

Mouse Anti-JMJD1C Recombinant Antibody (CBLXJ-038) (CBMAB-2197CQ)

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Target: JMJD1C

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLXJ-038

Application*: WB, P, F

Mouse Anti-JMJD1C Recombinant Antibody (CBLXJ-039) (CBMAB-2157CQ)

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Target: JMJD1C

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLXJ-039

Application*: E, P, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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