Mouse Anti-JMJD6 Recombinant Antibody (A725) (CBMAB-AP10943LY)

Name: Mouse Anti-JMJD6 Recombinant Antibody (A725)
SKU: CBMAB-AP10943LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A725

Application

ICC, WB

Immunogen

Synthetic peptide, corresponding to the N-terminus of Human JMJD6

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

Entrez Gene ID

23210

UniProt ID

Q6NYC1

Alternative Names

PSR, PTDSR, PTDSR1, KIAA0585, jumonji domain containing 6, Lysyl-hydroxylase JMJD6, Phosphatidylserine receptor, PTDSR, KIAA0585, Histone arginine demethylase JMJD6, JmjC domain-containing protein 6, PSR, Peptide-lysine 5-dioxygenase JMJD6, Protein PTDSR

Function

MB0100

Biological Process

Cell surface receptor signaling pathwayIEA:Ensembl
Chromatin organizationIEA:UniProtKB-KW
Erythrocyte developmentIEA:Ensembl
Heart developmentIEA:Ensembl
Histone H3-R2 demethylationManual Assertion Based On ExperimentIDA:BHF-UCL
Histone H4-R3 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Kidney developmentIEA:Ensembl
Lung developmentIEA:Ensembl
Macrophage activationIEA:Ensembl
mRNA processingIEA:UniProtKB-KW
Oxidative RNA demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-lysine hydroxylation to 5-hydroxy-L-lysineManual Assertion Based On ExperimentIDA:UniProtKB
PhagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Protein demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein homooligomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Recognition of apoptotic cellIEA:Ensembl
Regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIMP:UniProtKB
Retina development in camera-type eyeIEA:Ensembl
RNA splicingIEA:UniProtKB-KW
Sprouting angiogenesisISS:UniProtKB
T cell differentiation in thymusIEA:Ensembl

Cellular Location

Nucleus, nucleoplasm; Nucleus, nucleolus; Cytoplasm. Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.

PTM

Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.

Xiao, R. Q., Ran, T., Huang, Q. X., Hu, G. S., Fan, D. M., Yi, J., & Liu, W. (2022). A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo. Proceedings of the National Academy of Sciences, 119(34), e2200753119.

Wang, K., Yang, C., Li, H., Liu, X., Zheng, M., Xuan, Z., ... & Wang, H. (2022). Role of the epigenetic modifier JMJD6 in tumor development and regulation of immune response. Frontiers in immunology, 13, 859893.

Paschalis, A., Welti, J., Neeb, A. J., Yuan, W., Figueiredo, I., Pereira, R., ... & de Bono, J. S. (2022). JMJD6 is a druggable oxygenase that regulates AR-V7 expression in prostate cancer. Cancer research, 81(4), 1087-1100.

Cockman, M. E., Sugimoto, Y., Pegg, H. B., Masson, N., Salah, E., Tumber, A., ... & Ratcliffe, P. J. (2022). Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6. Proceedings of the National Academy of Sciences, 119(32), e2201483119.

Wang, T., Zhang, R., Liu, Y., Fang, Z., Zhang, H., Fan, Y., ... & Xiang, R. (2021). Discovery of a new class of JMJD6 inhibitors and structure–activity relationship study. Bioorganic & Medicinal Chemistry Letters, 44, 128109.

Biswas, A., Mukherjee, G., Kondaiah, P., & Desai, K. V. (2020). Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer. BMC cancer, 20(1), 1-12.

Huo, D., Chen, H., Cheng, Y., Song, X., Zhang, K., Li, M. J., & Xuan, C. (2020). JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity. Cell Death & Differentiation, 27(3), 1052-1066.

Wong, M., Sun, Y., Xi, Z., Milazzo, G., Poulos, R. C., Bartenhagen, C., ... & Liu, T. (2019). JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma. Nature Communications, 10(1), 3319.

Wan, J., Liu, H., Yang, L., Ma, L., Liu, J., & Ming, L. (2019). JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4. International Journal of Cancer, 144(10), 2489-2500.

Ran, T., Xiao, R., Huang, Q., Yuan, H., Lu, T., & Liu, W. (2019). In silico discovery of JMJD6 inhibitors for cancer treatment. ACS Medicinal Chemistry Letters, 10(12), 1609-1613.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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