Mouse Anti-KATNAL1 Recombinant Antibody (6A4) (CBMAB-K0446-LY)

Name: Mouse Anti-KATNAL1 Recombinant Antibody (6A4)
SKU: CBMAB-K0446-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6A4

Application

FC, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.45 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Katanin Catalytic Subunit A1 Like 1

Introduction

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214).

Entrez Gene ID

84056

UniProt ID

Q9BW62

Alternative Names

Katanin Catalytic Subunit A1 Like 1; Katanin P60 Subunit A-Like 1; EC 3.6.4.3; Katanin Catalytic Subunit A Like 1; Katanin P60 Subunit A Like 1; P60 Katanin-Like 1;

Function

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity).
Has microtubule-severing activity in vitro (PubMed:26929214).

Biological Process

Microtubule severingManual Assertion Based On ExperimentIDA:UniProtKB
SpermatogenesisIEA:UniProtKB-UniRule

Cellular Location

Cytoplasm, cytoskeleton; Cytoplasm; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, spindle. Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity).
Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214).

Dunleavy, J. E., Graffeo, M., Wozniak, K., O'Connor, A. E., Merriner, D. J., Nguyen, J., ... & O'Bryan, M. K. (2023). Katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility. Development, dev-201956.

Cerván‐Martín, M., Bossini‐Castillo, L., Guzmán‐Jiménez, A., Rivera‐Egea, R., Garrido, N., Lujan, S., ... & Carmona, F. D. (2022). Common genetic variation in KATNAL1 non‐coding regions is involved in the susceptibility to severe phenotypes of male infertility. Andrology, 10(7), 1339-1350.

Kang, K., Li, N., Gao, Y., Wang, C., Chen, P., Meng, X., ... & Yu, K. (2022). circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis. Mediators of Inflammation, 2022.

Hatakeyama, E., & Hayashi, K. (2018). KATNAL1 is a more active and stable isoform of katanin, and is expressed dominantly in neurons. Biochemical and biophysical research communications, 507(1-4), 389-394.

Banks, G., Lassi, G., Hoerder-Suabedissen, A., Tinarelli, F., Simon, M. M., Wilcox, A., ... & Nolan, P. M. (2018). A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies. Molecular psychiatry, 23(3), 713-722.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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