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Mouse Anti-KCNE4 Recombinant Antibody (1D7) (CBMAB-K0530-LY)

This product is antibody recognizes KCNE4. The antibody 1D7 immunoassay techniques such as: ELISA, WB.
See all KCNE4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D7
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-171 from KCNE4 (AAH14429) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium voltage-gated channel, Isk-related family, member 4
Introduction
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
Entrez Gene ID
23704
UniProt ID
Q8WWG9
Alternative Names
Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4; Potassium Channel; Voltage Gated Subfamily E Regulatory Beta Subunit 4; Potassium Voltage-Gated Channel; Isk-Related Family; Member 4; Minimum Potassium Ion Channel-Related Peptide 3; Potassium Channel Subunit Beta MiRP3; Cardiac Voltage-Gated Potassium Channel Accessory Subunit 4;
Function
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
Biological Process
Membrane repolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Membrane repolarization during ventricular cardiac muscle cell action potentialIEA:GOC
Negative regulation of delayed rectifier potassium channel activityManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion export across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIBA:GO_Central
Ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Extracellular: 1-86
Helical: 87-107
Cytoplasmic: 108-221

Tian, K., Tao, Z., Chen, Y., Du, J., Chen, M., Wang, D., & Li, Z. (2023). KCNE4 expression is correlated with the pathological characteristics of colorectal cancer patients and associated with the radioresistance of cancer cells. Pathology-Research and Practice, 241, 154234.

Colomer-Molera, M., Sastre, D., Codina, L. S., Vallejo-Gracia, A., Perez, M. N., Capera-Aragones, J., ... & Felipe, A. (2023). Kv1. 3-dependent immune system activation is regulated by KCNE4. Biophysical Journal, 122(3), 14a.

Villegas-Esguevillas, M., Cho, S., Vera-Zambrano, A., Kwon, J. W., Barreira, B., Telli, G., ... & Cogolludo, A. (2023). The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. Biomedicine & Pharmacotherapy, 164, 114952.

Mano, R., Tanaka, T., Hashiguchi, S., Takahashi, H., Sakata, N., Kondo, S., & Kodama, S. (2022). Induction of potassium channel regulator KCNE4 in a submandibular lymph node metastasis model. Scientific Reports, 12(1), 13208.

Roig, S. R., Solé, L., Cassinelli, S., Colomer-Molera, M., Sastre, D., Serrano-Novillo, C., ... & Felipe, A. (2021). Calmodulin-dependent KCNE4 dimerization controls membrane targeting. Scientific reports, 11(1), 14046.

Vallejo-Gracia, A., Sastre, D., Colomer-Molera, M., Solé, L., Navarro-Pérez, M., Capera, J., ... & Felipe, A. (2021). KCNE4-dependent functional consequences of Kv1. 3-related leukocyte physiology. Scientific reports, 11(1), 14632.

Solé, L., Sastre, D., Colomer-Molera, M., Vallejo-Gracia, A., Roig, S. R., Pérez-Verdaguer, M., ... & Felipe, A. (2020). Functional consequences of the variable stoichiometry of the Kv1. 3-KCNE4 complex. Cells, 9(5), 1128.

Lee, J. E., Park, C. H., Kang, H., Ko, J., Cho, S., Woo, J., ... & So, I. (2020). The agonistic action of URO-K10 on Kv7. 4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 24(6), 503-516.

Sole, L., Roig, S. R., Sastre, D., Vallejo-Gracia, A., Serrano-Albarrás, A., Ferrer-Montiel, A., ... & Felipe, A. (2019). The calmodulin‐binding tetraleucine motif of KCNE4 is responsible for association with Kv1. 3. The FASEB Journal, 33(7), 8263-8279.

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For research use only. Not intended for any clinical use.

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