KCNE4

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq]

Full Name

potassium voltage-gated channel, Isk-related family, member 4

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

Biological Process

Membrane repolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Membrane repolarization during ventricular cardiac muscle cell action potentialIEA:GOC
Negative regulation of delayed rectifier potassium channel activityManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion export across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIBA:GO_Central
Ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 1-86
Helical: 87-107
Cytoplasmic: 108-221