Mouse Anti-KCNJ12 Recombinant Antibody (S124B-38) (CBMAB-K0053-LY)

Name: Mouse Anti-KCNJ12 Recombinant Antibody (S124B-38)
SKU: CBMAB-K0053-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

S124B-38

Application

ICC, IHC-P, WB

Specificity

Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% Glycerol

Preservative

0.1% sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Potassium Voltage-Gated Channel Subfamily J Member 12

Introduction

This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Entrez Gene ID

117052

UniProt ID

P52188

Alternative Names

IRK2; Kir2.1; Kir2.2

Function

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Biological Process

Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Potassium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Protein homotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of heart contractionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-82
Helical: 83-107
Extracellular: 108-123
Helical: 124-141
Pore-forming: 142-151
Extracellular: 152-156
Helical: 157-181
Cytoplasmic: 182-433

Wang, J., Wen, Y., Xu, J., Yue, B., Zhong, J., Zheng, L., ... & Huang, Y. (2022). Circ RIMKLB promotes myoblast proliferation and inhibits differentiation by sponging miR-29c to release KCNJ12. Epigenetics, 17(12), 1686-1700.

Chen, K., Hu, Y. Y., Wang, L. L., Xia, Y., Jiang, Q., Sun, L., ... & Li, D. S. (2022). Whole-Genome Sequencing Identified KCNJ12 and SLC25A5 Mutations in Port-Wine Stains. Frontiers in Medicine, 9, 905902.

Li, G., Guo, B. Y., Wang, H. D., Lin, G. T., Lan, T. J., Ying, H., & Xu, J. (2021). CircRNA hsa_circ_0014130 function as a miR-132-3p sponge for playing oncogenic roles in bladder cancer via upregulating KCNJ12 expression. Cell biology and toxicology, 1-18.

Zhang, X., Liao, C., Sun, K., Liu, L., & Xu, D. (2020, August). A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction. In The Heart Surgery Forum (Vol. 23, No. 5, pp. E579-E585).

Cheng, J., Peng, W., Cao, X., Huang, Y., Lan, X., Lei, C., & Chen, H. (2019). A Missense Mutation in KCNJ12 Was Strongly Associated with Beef Cattle Stature.

Cheng, J., Peng, W., Cao, X., Huang, Y., Lan, X., Lei, C., & Chen, H. (2019). Differential expression of KCNJ12 gene and association analysis of its missense mutation with growth traits in chinese cattle. Animals, 9(5), 273.

Zheng, L., Xu, J. W., Li, J. C., Wang, D. H., An, Q. M., Xu, L. N., ... & Huang, Y. Z. (2019). Distribution and association study in copy number variation of KCNJ12 gene across four Chinese cattle populations. Gene, 689, 90-96.

Khalilipour, N., Baranova, A., Jebelli, A., Heravi-Moussavi, A., Bruskin, S., & Abbaszadegan, M. R. (2018). Familial esophageal squamous cell carcinoma with damaging rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes. Cancer genetics, 221, 46-52.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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