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Mouse Anti-KCNJ12 Recombinant Antibody (S124B-38) (CBMAB-K0053-LY)

This product is antibody recognizes KCNJ12. The antibody S124B-38 immunoassay techniques such as: ICC, IHC-P, WB.
See all KCNJ12 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
S124B-38
Antibody Isotype
IgG1
Application
ICC, IHC-P, WB

Basic Information

Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol
Preservative
0.1% sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Voltage-Gated Channel Subfamily J Member 12
Introduction
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Entrez Gene ID
117052
UniProt ID
P52188
Alternative Names
IRK2; Kir2.1; Kir2.2
Function
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Biological Process
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Potassium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Protein homotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of heart contractionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-82
Helical: 83-107
Extracellular: 108-123
Helical: 124-141
Pore-forming: 142-151
Extracellular: 152-156
Helical: 157-181
Cytoplasmic: 182-433

Wang, J., Wen, Y., Xu, J., Yue, B., Zhong, J., Zheng, L., ... & Huang, Y. (2022). Circ RIMKLB promotes myoblast proliferation and inhibits differentiation by sponging miR-29c to release KCNJ12. Epigenetics, 17(12), 1686-1700.

Chen, K., Hu, Y. Y., Wang, L. L., Xia, Y., Jiang, Q., Sun, L., ... & Li, D. S. (2022). Whole-Genome Sequencing Identified KCNJ12 and SLC25A5 Mutations in Port-Wine Stains. Frontiers in Medicine, 9, 905902.

Li, G., Guo, B. Y., Wang, H. D., Lin, G. T., Lan, T. J., Ying, H., & Xu, J. (2021). CircRNA hsa_circ_0014130 function as a miR-132-3p sponge for playing oncogenic roles in bladder cancer via upregulating KCNJ12 expression. Cell biology and toxicology, 1-18.

Zhang, X., Liao, C., Sun, K., Liu, L., & Xu, D. (2020, August). A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction. In The Heart Surgery Forum (Vol. 23, No. 5, pp. E579-E585).

Cheng, J., Peng, W., Cao, X., Huang, Y., Lan, X., Lei, C., & Chen, H. (2019). A Missense Mutation in KCNJ12 Was Strongly Associated with Beef Cattle Stature.

Cheng, J., Peng, W., Cao, X., Huang, Y., Lan, X., Lei, C., & Chen, H. (2019). Differential expression of KCNJ12 gene and association analysis of its missense mutation with growth traits in chinese cattle. Animals, 9(5), 273.

Zheng, L., Xu, J. W., Li, J. C., Wang, D. H., An, Q. M., Xu, L. N., ... & Huang, Y. Z. (2019). Distribution and association study in copy number variation of KCNJ12 gene across four Chinese cattle populations. Gene, 689, 90-96.

Khalilipour, N., Baranova, A., Jebelli, A., Heravi-Moussavi, A., Bruskin, S., & Abbaszadegan, M. R. (2018). Familial esophageal squamous cell carcinoma with damaging rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes. Cancer genetics, 221, 46-52.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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