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Mouse Anti-KCNJ15 Recombinant Antibody (1B2) (CBMAB-K0565-LY)

This product is antibody recognizes KCNJ15. The antibody 1B2 immunoassay techniques such as: WB.
See all KCNJ15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B2
Antibody Isotype
IgG2a, κ
Application
WB

Basic Information

Immunogen
KCNJ15 (290 a.a. ~ 356 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium inwardly-rectifying channel, subfamily J, member 15
Introduction
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
Entrez Gene ID
UniProt ID
Alternative Names
Potassium Voltage-Gated Channel Subfamily J Member 15; Potassium Inwardly-Rectifying Channel; Subfamily J; Member 15; Potassium Channel; Inwardly Rectifying Subfamily J Member 15; Inward Rectifier K(+) Channel Kir1.3; Inward Rectifier K(+) Channel Kir4.2; ATP-Sensitive Inward Rectifier Potassium Channel 15;
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Biological Process
Potassium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Topology
Cytoplasmic: 1-63
Helical: 64-88
Extracellular: 89-113
Helical: 114-125
Pore-forming: 126-132
Extracellular: 133-141
Helical: 142-163
Cytoplasmic: 164-375

Zhou, S. Z., Shen, L., Fu, Z. B., Li, H., Pan, Y. L., & Yu, R. Z. (2023). Exploring the common diagnostic gene KCNJ15 and shared pathway of ankylosing spondylitis and ulcerative colitis through integrated bioinformatics. Frontiers in Physiology, 14, 624.

Qiao, X., Zhang, Y., Zhang, Z., Niu, N., Li, H., Sun, L., ... & Liu, C. (2023). KCNJ15 deficiency promotes drug resistance via affecting the function of lysosomes. Asian Journal of Pharmaceutical Sciences, 18(3), 100814.

Wang, S., Li, Z., Ding, X., Zhao, Z., Zhang, M., Xu, H., ... & Dai, L. (2022). Integrative Analyses Identify KCNJ15 as a Candidate Gene in Patients with Epilepsy. Neurology and Therapy, 11(4), 1767-1776.

Nakamura, S., Kanda, M., Koike, M., Shimizu, D., Umeda, S., Hattori, N., ... & Kodera, Y. (2020). KCNJ15 expression and malignant behavior of esophageal squamous cell carcinoma. Annals of Surgical Oncology, 27, 2559-2568.

Nakamura, S., Kanda, M., & Kodera, Y. (2020). ASO Author Reflections: KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma. Annals of Surgical Oncology, 27, 2569-2570.

Liu, Y., Wang, H., Ni, B., Zhang, J., Li, S., Huang, Y., ... & Li, Z. (2019). Loss of KCNJ15 expression promotes malignant phenotypes and correlates with poor prognosis in renal carcinoma. Cancer Management and Research, 1211-1220.

Liu, Y., Ni, B., Li, S., Huang, Y., Mei, H., & Li, Z. (2018). AB026. Loss of KCNJ15 expression promotes malignant phenotypes and correlates with poor prognosis in renal carcinoma. Translational Andrology and Urology, 7(Suppl 5).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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