Sign in or Register   Sign in or Register
  |  

Rabbit Anti-KCNJ3 Recombinant Antibody (BA0312) (CBMAB-0421CQ)

This product is a rabbit antibody that recognizes KCNJ3. The antibody BA0312 can be used for immunoassay techniques such as: FC, WB.
See all KCNJ3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0312
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Synthetic peptide from residues in the extracellular domain of Human GIRK1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Potassium Voltage-Gated Channel Subfamily J Member 3
Introduction
KCNJ3 combines with other KCNJ subunits to form heterotetrameric potassium current channels that are activated via stimulation of G protein-coupled receptors. KCNJ subunits contain 2 transmembrane domains, in contrast with the 6 transmembrane domains of their voltage-gated potassium channel relatives, and they have the characteristic potassium ion selectivity filter sequence (GYG) in their pore domain. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Entrez Gene ID
Human3760
Mouse16519
Rat50599
UniProt ID
HumanP48549
MouseP63250
RatP63251
Alternative Names
KGA; GIRK1; KIR3.1
Function
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Biological Process
Membrane repolarization during atrial cardiac muscle cell action potential1 PublicationIC:BHF-UCL
Potassium ion import across plasma membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of heart rate by cardiac conduction1 PublicationIC:BHF-UCL
Regulation of ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Response to electrical stimulusIEA:Ensembl
Ventricular cardiac muscle cell membrane repolarization1 PublicationIC:BHF-UCL
Cellular Location
Membrane
Topology
Cytoplasmic: 1-80
Helical: 81-105
Extracellular: 106-129
Helical: 130-141
Pore-forming: 142-148
Extracellular: 149-157
Helical: 158-179
Cytoplasmic: 180-501
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-KCNJ3 Recombinant Antibody (BA0312)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare